TBX6抗体

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P07298(TBX6 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The T-box transcription factor 6 (TBX6) is a member of the T-box gene family, which plays critical roles in embryonic development, particularly in somitogenesis, mesoderm specification, and organogenesis. TBX6 is highly conserved across vertebrates and is essential for the formation of paraxial mesoderm-derived structures, including the somites that give rise to skeletal muscle, vertebrae, and dermis. In humans, TBX6 mutations or deletions are linked to congenital vertebral malformations, such as congenital scoliosis, highlighting its importance in axial skeletal development.

TBX6 antibodies are immunological tools designed to detect and quantify TBX6 protein expression in research settings. These antibodies are typically generated using immunogenic peptides or recombinant protein fragments of TBX6 and are validated for applications like Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. They enable the study of TBX6's spatial and temporal expression patterns during embryogenesis, its interaction with signaling pathways (e.g., Wnt/β-catenin or Notch), and its role in disease models. Specificity is a key consideration, as cross-reactivity with other T-box family members (e.g., TBX4 or TBX5) must be ruled out. TBX6 antibodies are also utilized in clinical research to explore genetic disorders associated with developmental defects, offering insights into molecular mechanisms and potential therapeutic targets.