IRAK1BP1抗体,Rabbit Polyclonal IRAK1BP1 Antibody
  • IRAK1BP1抗体,Rabbit Polyclonal IRAK1BP1 Antibody
  • IRAK1BP1抗体,Rabbit Polyclonal IRAK1BP1 Antibody
  • IRAK1BP1抗体,Rabbit Polyclonal IRAK1BP1 Antibody

IRAK1BP1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
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产品详情

中文名称:IRAK1BP1抗体英文名称:Rabbit Polyclonal IRAK1BP1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3519 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: IRAK1BP1
2025-05-13 IRAK1BP1抗体 Rabbit Polyclonal IRAK1BP1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3519 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/200-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesAIP70; SIMPL
WB Predicted band size29 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human IRAK1BP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: P07395(IRAK1BP1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P07395(IRAK1BP1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07395(IRAK1BP1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于IRAK1BP1抗体的3篇参考文献示例(注:文献为模拟示例,实际引用需核实):

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1. **Title**: IRAK1BP1 regulates TLR-induced NF-κB activation by targeting IKK complexes

**Author**: Smith J, et al.

**Summary**: 本研究利用IRAK1BP1特异性抗体,通过免疫共沉淀(Co-IP)和Western blot技术,发现IRAK1BP1通过结合IKKγ(NEMO)抑制TLR信号通路中NF-κB的过度激活,揭示了其在炎症反应中的负调控机制。

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2. **Title**: Autophagy-dependent degradation of IRAK1BP1 modulates inflammatory responses

**Author**: Chen L, et al.

**Summary**: 通过免疫荧光和流式细胞术结合IRAK1BP1抗体,作者证实IRAK1BP1在巨噬细胞自噬过程中被选择性降解,其稳定性丧失导致IL-1β分泌增加,提示其通过自噬-炎症串扰调控先天免疫。

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3. **Title**: IRAK1BP1 antibody-based screening identifies its overexpression in rheumatoid arthritis

**Author**: Wang Y, et al.

**Summary**: 研究采用IRAK1BP1抗体对类风湿关节炎患者滑膜组织进行免疫组化分析,发现IRAK1BP1蛋白水平与疾病严重程度呈负相关,提示其可能作为炎症性关节病的潜在生物标志物。

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如需实际文献,建议在PubMed等数据库中检索关键词:**IRAK1BP1 antibody** 或 **IRAK1BP1 function**,并筛选涉及抗体应用的研究。

       

背景信息

The IRAK1BP1 (Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1) antibody is a tool used to detect and study the IRAK1BP1 protein, which plays a regulatory role in innate immune signaling pathways. IRAK1BP1. also known as SIMPL (STAT-interacting MAPK pathway-associated protein), interacts with components of the interleukin-1 receptor (IL-1R) and Toll-like receptor (TLR) signaling cascades, particularly modulating NF-κB activation. It acts as a negative regulator, fine-tuning inflammatory responses by inhibiting IRAK1-dependent signaling, thus influencing cytokine production and immune homeostasis.

Antibodies targeting IRAK1BP1 are widely utilized in research to investigate its expression, localization, and function in immune cells and disease models. These antibodies are commonly validated for applications like Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. Studies employing IRAK1BP1 antibodies have linked the protein to autoimmune diseases, chronic inflammation, and cancer, where dysregulated NF-κB signaling is often implicated. For instance, reduced IRAK1BP1 expression has been observed in certain cancers, suggesting its potential role as a tumor suppressor. Researchers also explore its involvement in crosstalk between innate immunity and other pathways, such as autophagy or apoptosis. The development of specific, high-affinity IRAK1BP1 antibodies has been critical in elucidating its molecular interactions and therapeutic relevance.

       
关键字: IRAK1BP1抗体;IRAK1BP1;IRAK1BP1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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