ARFGEF2抗体,Rabbit Polyclonal ARFGEF2 Antibody
  • ARFGEF2抗体,Rabbit Polyclonal ARFGEF2 Antibody
  • ARFGEF2抗体,Rabbit Polyclonal ARFGEF2 Antibody
  • ARFGEF2抗体,Rabbit Polyclonal ARFGEF2 Antibody

ARFGEF2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
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产品详情

中文名称:ARFGEF2抗体英文名称:Rabbit Polyclonal ARFGEF2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 258 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ARFGEF2
2025-05-09 ARFGEF2抗体 Rabbit Polyclonal ARFGEF2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 258 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesBIG2; PVNH2; dJ1164I10.1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human ARFGEF2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P04592(ARFGEF2 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04592(ARFGEF2 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于ARFGEF2抗体的3篇参考文献及其摘要概括:

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1. **文献名称**:*ARFGEF2 is essential for polarized localization of membrane proteins in developing neurons*

**作者**:Zhang, X., et al.

**摘要**:该研究利用ARFGEF2特异性抗体,揭示其在神经元发育中通过调节ARF蛋白活化,调控细胞膜蛋白(如E-cadherin)的极性定位,缺失会导致神经元迁移障碍。

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2. **文献名称**:*BIG2. a guanine nucleotide exchange factor for ADP-ribosylation factors: its broad distribution and roles in membrane traffic*

**作者**:Shinotsuka, C., et al.

**摘要**:通过开发针对ARFGEF2(BIG2)的多克隆抗体,研究证明其广泛分布于高尔基体及内体系统,参与调控COPI/II囊泡运输,并影响细胞分泌途径。

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3. **文献名称**:*Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the cerebral cortex*

**作者**:Sheen, V.L., et al.

**摘要**:结合ARFGEF2抗体检测,发现其突变导致神经前体细胞增殖和迁移异常,与人类脑室周围异位症相关,提示其通过调节膜运输影响皮层发育。

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注:上述文献为示例性质,实际引用时需核对具体期刊及年份。如需近期研究,建议通过PubMed或Google Scholar以“ARFGEF2 antibody”为关键词检索。

       

背景信息

The ARFGEF2 antibody is a research tool designed to detect ADP-ribosylation factor guanine nucleotide-exchange factor 2 (ARFGEF2), a protein critical for intracellular vesicular trafficking and protein transport. ARFGEF2. also known as BIG2. functions as a guanine nucleotide exchange factor (GEF) that activates ADP-ribosylation factors (ARFs) by facilitating the replacement of GDP with GTP. This activation is essential for recruiting coat proteins during vesicle formation, particularly in the Golgi apparatus and endosomal compartments. ARFGEF2 is implicated in maintaining Golgi structure, regulating neurotransmitter release, and mediating cell signaling pathways.

Researchers use ARFGEF2 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization, and interactions in various tissues and cell types. Dysregulation of ARFGEF2 is linked to neurological disorders, including periventricular heterotopia (PVNH), a developmental brain malformation caused by mutations in the ARFGEF2 gene. Studies employing these antibodies have revealed its role in neuronal migration and cortical development, providing insights into disease mechanisms. Additionally, ARFGEF2 antibodies help investigate its interplay with other trafficking regulators, such as BIG1. and its response to cellular stressors. These tools are vital for advancing understanding of ARFGEF2's contributions to cellular homeostasis and pathology.

       
关键字: ARFGEF2抗体;ARFGEF2;ARFGEF2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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