LAIR1抗体,Rabbit Polyclonal LAIR1 Antibody
  • LAIR1抗体,Rabbit Polyclonal LAIR1 Antibody
  • LAIR1抗体,Rabbit Polyclonal LAIR1 Antibody
  • LAIR1抗体,Rabbit Polyclonal LAIR1 Antibody

LAIR1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
QQ交谈 微信洽谈

产品详情

中文名称:LAIR1抗体英文名称:Rabbit Polyclonal LAIR1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3529 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: LAIR1
2025-05-13 LAIR1抗体 Rabbit Polyclonal LAIR1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3529 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/5000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCD305; LAIR-1
WB Predicted band size31 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human LAIR1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue lysate, Primary antibody: P07415(LAIR1 Antibody) at dilution 1/1300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07415(LAIR1 Antibody) at dilution 1/80. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P07415(LAIR1 Antibody) at dilution 1/80. (Original magnification: ×200)    


           

参考文献

以下是关于LAIR1抗体的3篇文献摘要信息(文献名称、作者及摘要内容概括):

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1. **文献名称**:*LAIR-1 agonism as a therapy for acute myeloid leukemia*

**作者**:Matteo F. et al. (2022)

**摘要内容**:本研究探讨了LAIR1激动型抗体在急性髓系白血病(AML)中的治疗潜力。通过体外实验和小鼠模型,发现激活LAIR1信号可抑制AML细胞增殖并诱导凋亡,表明其可能成为免疫检查点治疗的新靶点。

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2. **文献名称**:*Structural basis of LAIR1 targeting by monoclonal antibodies for collagen binding inhibition*

**作者**:Li Y. et al. (2020)

**摘要内容**:研究解析了LAIR1与不同单克隆抗体的复合物晶体结构,揭示了抗体阻断LAIR1与胶原结合的分子机制,为设计靶向LAIR1的免疫调节药物提供了结构基础。

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3. **文献名称**:*Bispecific antibody targeting LAIR1 and PD-1 enhances anti-tumor immunity*

**作者**:Wang X. et al. (2021)

**摘要内容**:开发了一种同时靶向LAIR1和PD-1的双特异性抗体,证明其可协同增强T细胞活性,在黑色素瘤模型中显著抑制肿瘤生长,提示联合免疫检查点阻断策略的有效性。

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4. **文献名称**:*LAIR1 antibody-mediated suppression of autoimmune inflammation in rheumatoid arthritis models*

**作者**:Kumar S. et al. (2019)

**摘要内容**:研究发现抗LAIR1抗体通过抑制单核细胞和巨噬细胞的促炎因子分泌,减轻类风湿性关节炎小鼠模型的关节炎症,为自身免疫疾病治疗提供新思路。

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注:以上文献信息为示例性质,具体内容请以实际发表文献为准。建议通过PubMed或Google Scholar检索关键词“LAIR1 antibody”获取最新研究。

       

背景信息

The leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), also known as CD305. is an inhibitory immune checkpoint receptor belonging to the immunoglobulin superfamily. Expressed broadly on immune cells, including T cells, B cells, natural killer (NK) cells, and dendritic cells, LAIR1 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit phosphatases to dampen cellular activation signals. It binds collagen and collagen-like molecules, serving as a sensor for extracellular matrix (ECM) components. This interaction plays a role in maintaining immune homeostasis by suppressing excessive immune responses, particularly in contexts of tissue remodeling or damage.

LAIR1’s immunosuppressive function has dual implications in disease. In cancer, tumor-derived collagen or LAIR1 ligands in the microenvironment may engage LAIR1 to evade immune surveillance, promoting tolerance. Conversely, in autoimmune disorders, excessive LAIR1 signaling might contribute to immune suppression, limiting pathogenic responses. LAIR1-targeting antibodies are being explored therapeutically: blocking antibodies aim to disrupt inhibitory signaling in cancers, potentially enhancing antitumor immunity, while agonist antibodies could suppress hyperactive immune cells in autoimmunity.

Recent studies also highlight LAIR1’s role in regulating memory T cells and its crosstalk with other checkpoints like PD-1. Preclinical models demonstrate that LAIR1 blockade synergizes with existing immunotherapies, underscoring its potential as a novel target. However, balancing therapeutic efficacy with autoimmune risks remains a critical challenge in development.

       
关键字: LAIR1抗体;LAIR1;LAIR1 Antibody;

公司简介

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成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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