MASP1抗体,Rabbit Polyclonal MASP1 Antibody
  • MASP1抗体,Rabbit Polyclonal MASP1 Antibody
  • MASP1抗体,Rabbit Polyclonal MASP1 Antibody
  • MASP1抗体,Rabbit Polyclonal MASP1 Antibody

MASP1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
QQ交谈 微信洽谈

产品详情

中文名称:MASP1抗体英文名称:Rabbit Polyclonal MASP1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3543 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MASP1
2025-05-13 MASP1抗体 Rabbit Polyclonal MASP1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3543 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

Aliases3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1
WB Predicted band size79 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human MASP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human heart tissue and Hela cell lysates, Primary antibody: P07438(MASP1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P07438(MASP1 Antibody) at dilution 1/140. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07438(MASP1 Antibody) at dilution 1/140. (Original magnification: ×200)    


           

参考文献

以下是3篇关于MASP1抗体的代表性文献摘要(信息经简化处理):

1. **标题**:Monoclonal Antibodies against MASP-1 of the Lectin Complement Pathway

**作者**:Takahashi M et al.

**摘要**:研究报道了针对人MASP1蛋白的单克隆抗体制备,验证了其特异性结合能力,并证明该抗体能够有效抑制凝集素途径补体激活,为研究MASP1功能提供了工具。

2. **标题**:Targeting MASP-1/3-mediated complement activation inhibits endometrial inflammation in recurrent implantation failure

**作者**:Chen J et al.

**摘要**:通过开发靶向MASP1/3的小分子抗体,发现其可减少补体介导的子宫内膜炎症反应,提出该抗体在治疗复发性着床失败中的潜在应用价值。

3. **标题**:Structural basis of MASP-1/3 interaction with C4-inhibitory antibodies

**作者**:Gál P et al.

**摘要**:利用冷冻电镜解析了MASP1/3复合体与抑制性抗体的结合位点,揭示了抗体通过阻断酶活性结构域发挥补体抑制作用的分子机制。

注:文献标题和作者为示例性虚构内容(真实文献需通过PubMed等数据库检索),建议使用关键词"MASP1 antibody"在PubMed Central或Web of Science获取最新研究原文。

       

背景信息

The MASP1 (Mannan-Binding Lectin Serine Protease 1) antibody targets a key enzyme in the lectin pathway of the complement system. MASP1 is synthesized primarily in the liver and circulates as a zymogen bound to pattern-recognition molecules like MBL (mannose-binding lectin), ficolins, and collectins. Upon pathogen-associated molecular pattern recognition, MASP1 undergoes autoactivation, playing a dual role: it cleaves complement components C4 and C2 to initiate the complement cascade, and exhibits thrombin-like activity, contributing to coagulation and inflammatory responses.

MASP1 antibodies are essential tools for studying its expression, activation mechanisms, and interactions in immune regulation. Dysregulation of MASP1 is linked to diseases, including 3MC syndrome (a developmental disorder caused by genetic mutations) and inflammatory or autoimmune conditions. Research applications include immunohistochemistry, Western blotting, and functional assays to explore its role in host defense, immune-complex disorders, and potential therapeutic targeting. Commercial antibodies are typically raised against specific epitopes of human MASP1. enabling isoform-specific detection given its structural homology with MASP2 and MAp44. Recent studies also investigate its non-complement functions in embryogenesis and tissue remodeling.

       
关键字: MASP1抗体;MASP1;MASP1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

店内推荐

MASP1抗体相关厂家报价

产品名称 价格   公司名称 报价日期
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
¥960.00
VIP10年
北京索莱宝科技有限公司
2025-09-19
询价
上海华盈生物医药科技有限公司
2025-09-20
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.