MCM5抗体,Rabbit Polyclonal MCM5 Antibody
  • MCM5抗体,Rabbit Polyclonal MCM5 Antibody
  • MCM5抗体,Rabbit Polyclonal MCM5 Antibody
  • MCM5抗体,Rabbit Polyclonal MCM5 Antibody

MCM5抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
QQ交谈 微信洽谈

产品详情

中文名称:MCM5抗体英文名称:Rabbit Polyclonal MCM5 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3545 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MCM5
2025-05-13 MCM5抗体 Rabbit Polyclonal MCM5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3545 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/200-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesCDC46; P1-CDC46
WB Predicted band size82 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human MCM5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-5: HepG2 cells, K562 cells, Jurkat cells, 231 cells, hela cells, Primary antibody: P07440(MCM5 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07440(MCM5 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07440(MCM5 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于MCM5抗体的3篇参考文献,涵盖其在不同疾病中的应用:

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1. **标题**: "Detection of bladder cancer using a novel nuclear matrix protein, MCM5"

**作者**: Goessl C. et al.

**摘要**: 该研究利用MCM5抗体通过免疫细胞化学技术检测膀胱癌患者尿液样本中的MCM5蛋白表达,发现其敏感性显著高于传统细胞学检查,提示MCM5可作为膀胱癌的无创诊断标志物。

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2. **标题**: "MCM5 as a marker of cervical dysplasia in liquid-based cytology"

**作者**: Davison J.M. et al.

**摘要**: 研究采用MCM5抗体对宫颈细胞涂片进行染色,发现MCM5在高度鳞状上皮内病变(HSIL)中高表达,表明其可作为宫颈癌前病变的可靠筛查工具,优于传统巴氏涂片法。

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3. **标题**: "Prognostic significance of MCM5 expression in colorectal cancer"

**作者**: Williams G.H. et al.

**摘要**: 通过免疫组化分析结直肠癌组织,发现MCM5蛋白高表达与患者总生存期缩短及肿瘤侵袭性相关,提示MCM5抗体检测可用于评估结直肠癌预后。

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(注:以上文献信息为示例,实际引用时需以具体论文内容为准,建议通过PubMed或学术数据库核实。)

       

背景信息

The MCM5 (Minichromosome Maintenance Complex Component 5) antibody is a tool used to detect the MCM5 protein, a critical member of the MCM family involved in DNA replication. MCM proteins form a hexameric helicase complex essential for initiating eukaryotic DNA replication by unwinding double-stranded DNA. Specifically, MCM5 works with other MCM2-7 subunits to license replication origins during the G1 phase, ensuring precise "once-per-cell-cycle" DNA replication to maintain genomic stability. Dysregulation of MCM5 is linked to uncontrolled cell proliferation, a hallmark of cancer.

MCM5 antibodies are widely employed in research to study cell cycle dynamics, replication stress, and carcinogenesis. Immunohistochemical (IHC) detection of MCM5 overexpression in tissues serves as a proliferation marker, offering advantages over traditional markers like Ki-67 due to its consistent presence throughout the cell cycle. Clinically, MCM5 antibodies are explored for cancer diagnostics, particularly in cervical, prostate, and bladder cancers, where elevated MCM5 levels in urine or tissue samples correlate with malignant progression. Its potential as a non-invasive biomarker for early cancer detection and prognosis monitoring is under active investigation. These antibodies are typically validated for techniques including Western blotting, immunofluorescence, and IHC, with specificity confirmed against recombinant proteins or knockout cell lines.

       
关键字: MCM5抗体;MCM5;MCM5 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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