NEUROG3抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human heart tissue lysate, Primary antibody: P07483(NEUROG3 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 second    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07483(NEUROG3 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

NEUROG3 (Neurogenin 3) is a basic helix-loop-helix (bHLH) transcription factor critical for endocrine cell differentiation during development. It serves as a master regulator in the formation of pancreatic islet cells and intestinal enteroendocrine cells. NEUROG3 antibodies are essential tools for detecting and studying the expression, localization, and function of this protein in developmental biology, diabetes research, and gastrointestinal studies. These antibodies are typically generated against specific epitopes of human or murine NEUROG3. often targeting its C-terminal or N-terminal regions.

Validated in assays like immunohistochemistry (IHC), Western blot, and immunofluorescence (IF), NEUROG3 antibodies help identify progenitor cells committing to endocrine lineages. Researchers use them to investigate NEUROG3's role in diseases such as neonatal diabetes, maturity-onset diabetes of the young (MODY), and neuroendocrine tumors, where its expression or mutations may disrupt normal cell differentiation. Commercial NEUROG3 antibodies are available as monoclonal or polyclonal formats, often verified in knockout models to ensure specificity.

Studies leveraging these antibodies have clarified mechanisms of β-cell regeneration and intestinal hormone production, offering insights into therapeutic strategies for diabetes and gut disorders. Proper validation, including species reactivity and cross-reactivity checks, remains crucial due to NEUROG3's transient expression and low abundance in tissues.