**Background of NME6 Antibody**
The NME6 (non-metastatic protein 6) antibody is a tool used to detect and study the NME6 protein, a member of the NME/NM23 family of nucleoside diphosphate kinases (NDPKs). This evolutionarily conserved family regulates nucleotide metabolism by catalyzing the transfer of phosphate groups between nucleoside triphosphates and diphosphates. NME6. also termed NDK6 or Nm23-H6. is localized to mitochondria and nuclei, suggesting roles in cellular energy homeostasis, mitochondrial dynamics, and nuclear processes.
NME6 is implicated in diverse cellular functions, including apoptosis, autophagy, and DNA repair. Studies link it to mitochondrial network maintenance and interactions with proteins like Drp1. which governs mitochondrial fission. Dysregulation of NME6 has been explored in cancer, neurodegenerative disorders, and metabolic diseases, though its precise mechanisms remain under investigation.
The NME6 antibody is critical for applications like Western blotting, immunofluorescence, and immunohistochemistry, enabling researchers to analyze protein expression, localization, and interactions. It aids in elucidating NME6's biological significance, particularly its dual role in mitochondrial and nuclear pathways, and its potential as a biomarker or therapeutic target. Commercial NME6 antibodies are typically validated for specificity and sensitivity across human and model organisms.