TP73抗体,Rabbit Polyclonal TP73 Antibody
  • TP73抗体,Rabbit Polyclonal TP73 Antibody
  • TP73抗体,Rabbit Polyclonal TP73 Antibody
  • TP73抗体,Rabbit Polyclonal TP73 Antibody

TP73抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
QQ交谈 微信洽谈

产品详情

中文名称:TP73抗体英文名称:Rabbit Polyclonal TP73 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3580 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TP73
2025-05-13 TP73抗体 Rabbit Polyclonal TP73 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3580 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/200-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesP73
WB Predicted band size70 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human TP73
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 and HepG2 cell lysates, Primary antibody: P07516(TP73 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 40 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07516(TP73 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07516(TP73 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于TP73抗体的3篇参考文献,按简洁格式整理:

1. **"Monoclonal antibodies specific for p73: analysis of p73 expression in human tissues"**

*Authors: Fillippovich I, et al.*

摘要:开发了针对p73蛋白的特异性单克隆抗体,验证了其在Western blot和免疫组化中的应用,发现p73在多种肿瘤组织中高表达,与p53表达无显著相关性。

2. **"Differential roles of p63 and p73 in cancer development and therapeutic response"**

*Authors: Dulloo I, et al.*

摘要:通过多种TP73抗体对比研究p73亚型(TAp73/ΔNp73)的功能差异,发现TAp73具有肿瘤抑制活性,而ΔNp73可能促进肿瘤进展,提示抗体选择对研究结果的影响。

3. **"TP73 antibody validation for immunohistochemical analysis in glioblastoma"**

*Authors: Müller M, et al.*

摘要:系统验证了商用TP73抗体在胶质母细胞瘤组织中的特异性,发现部分抗体存在交叉反应(如与p63结合),推荐使用克隆号KTE13/KTE19以提高检测可靠性。

注:以上为示例性内容,实际文献需通过PubMed或Google Scholar检索确认。建议结合研究场景筛选抗体应用方向(如亚型检测、肿瘤类型等)。

       

背景信息

The TP73 antibody is a crucial tool in molecular and cancer research, targeting proteins encoded by the TP73 gene, a member of the p53 tumor suppressor family. The TP73 gene produces multiple isoforms through alternative splicing and promoter usage, primarily categorized as transcriptionally active (TAp73) and dominant-negative (ΔNp73) variants. TAp73 shares structural and functional similarities with p53. regulating cell cycle arrest, apoptosis, and DNA repair. In contrast, ΔNp73 lacks the transactivation domain and often antagonizes p53 and TAp73. promoting oncogenesis. TP73 dysregulation is implicated in various cancers, including neuroblastoma, leukemia, and solid tumors, with isoform imbalances influencing tumor progression and therapeutic resistance.

TP73 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect isoform-specific expression patterns, subcellular localization, and post-translational modifications. Their specificity is critical for distinguishing TP73 from homologous family members like p63. Research applications include elucidating TP73's role in tumor suppression, chemoresistance, and its crosstalk with oncogenic pathways. Commercial TP73 antibodies vary in clonality, epitope recognition, and validation standards, necessitating careful selection for experimental accuracy. Recent studies also explore TP73's potential as a prognostic biomarker and therapeutic target, underscoring the antibody's importance in both basic and translational oncology research.

       
关键字: TP73抗体;TP73;TP73 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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