ROCK2抗体,Rabbit Polyclonal ROCK2 Antibody
  • ROCK2抗体,Rabbit Polyclonal ROCK2 Antibody
  • ROCK2抗体,Rabbit Polyclonal ROCK2 Antibody
  • ROCK2抗体,Rabbit Polyclonal ROCK2 Antibody

ROCK2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
QQ交谈 微信洽谈

产品详情

中文名称:ROCK2抗体英文名称:Rabbit Polyclonal ROCK2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3622 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ROCK2
2025-05-13 ROCK2抗体 Rabbit Polyclonal ROCK2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3622 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesROCK-II
WB Predicted band size161 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human ROCK2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P07582(ROCK2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07582(ROCK2 Antibody) at dilution 1/130. (Original magnification: ×200)    


           

参考文献

以下是关于ROCK2抗体的3篇示例参考文献(注:文献信息为模拟示例,仅供参考):

---

1. **文献名称**:*"ROCK2-Specific Antibody Reveals Its Role in Cancer Cell Invasion via Cytoskeletal Remodeling"*

**作者**:Li, X. et al.

**摘要**:本研究利用ROCK2特异性抗体,通过免疫印迹和免疫荧光技术,揭示了ROCK2在乳腺癌细胞中通过调节肌动蛋白骨架促进侵袭转移的机制,并证明其与患者预后不良相关。

---

2. **文献名称**:*"Targeting ROCK2 with a Monoclonal Antibody Attenuates Neuroinflammation in Alzheimer's Disease Models"*

**作者**:Smith, J. & Patel, R.

**摘要**:文章报道了一种新型抗ROCK2单克隆抗体的开发,并在阿尔茨海默病小鼠模型中验证其效果。结果显示,该抗体通过抑制ROCK2活性减少tau蛋白过度磷酸化及神经炎症反应。

---

3. **文献名称**:*"ROCK2 Inhibition by a Neutralizing Antibody Improves Cardiac Fibrosis in Hypertensive Rats"*

**作者**:Yamamoto, K. et al.

**摘要**:研究使用ROCK2中和抗体干预高血压模型大鼠,发现其能显著降低心肌纤维化标志物(如胶原沉积),提示ROCK2抗体在心血管疾病治疗中的潜在应用价值。

---

如需真实文献,建议通过PubMed或Google Scholar搜索关键词(如“ROCK2 antibody”、“ROCK2 inhibitor”),并筛选近年高影响力期刊的研究(如*Nature Cell Biology*、*Journal of Biological Chemistry*等)。

       

背景信息

The Rho-associated coiled-coil kinase 2 (ROCK2) antibody is a crucial tool for studying the ROCK2 protein, a serine/threonine kinase belonging to the AGC family of kinases. ROCK2. along with its isoform ROCK1. plays a pivotal role in regulating cytoskeletal dynamics, cell adhesion, migration, and apoptosis through its interaction with Rho GTPases, particularly RhoA. It mediates downstream signaling by phosphorylating substrates such as myosin light chain (MLC) and LIM kinase, influencing actomyosin contractility and stress fiber formation.

ROCK2 is implicated in diverse physiological and pathological processes, including cardiovascular remodeling, neuronal degeneration, cancer metastasis, and fibrosis. Its overexpression or hyperactivity has been linked to hypertension, atherosclerosis, and glaucoma. The ROCK2 antibody enables detection and quantification of ROCK2 expression in tissues and cell lines via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It also aids in elucidating ROCK2's spatial-temporal localization and activation status under experimental or disease conditions.

Researchers frequently use ROCK2-specific antibodies to validate gene silencing (e.g., siRNA/CRISPR) or assess pharmacological inhibition by compounds like fasudil or Y-27632. As ROCK2-selective inhibitors gain traction in drug development, high-specificity antibodies are essential for distinguishing ROCK2 from ROCK1. which share ~65% homology but exhibit distinct tissue distributions and functions. This underscores the antibody's importance in both basic research and therapeutic targeting of ROCK2-associated pathways.

       
关键字: ROCK2抗体;ROCK2;ROCK2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

店内推荐

ROCK2抗体相关厂家报价

产品名称 价格   公司名称 报价日期
¥1098
VIP3年
上海沪震实业有限公司
2025-07-22
询价
VIP5年
上海冠导生物工程有限公司
2025-07-23
¥1600.00
VIP10年
北京索莱宝科技有限公司
2025-07-22
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.