NR0B2抗体,Rabbit Polyclonal NR0B2 Antibody
  • NR0B2抗体,Rabbit Polyclonal NR0B2 Antibody
  • NR0B2抗体,Rabbit Polyclonal NR0B2 Antibody
  • NR0B2抗体,Rabbit Polyclonal NR0B2 Antibody

NR0B2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
QQ交谈 微信洽谈

产品详情

中文名称:NR0B2抗体英文名称:Rabbit Polyclonal NR0B2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3626 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: NR0B2
2025-05-13 NR0B2抗体 Rabbit Polyclonal NR0B2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3626 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesSHP; SHP1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human NR0B2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07590(NR0B2 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07590(NR0B2 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于NR0B2抗体的3篇文献概览,包含文献名称、作者及摘要内容简述:

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1. **文献名称**:*"Development and Characterization of a Monoclonal Antibody Specific for Human NR0B2 (SHP)"*

**作者**:Zhang Y, et al.

**摘要**:本研究开发了一种针对人NR0B2蛋白的单克隆抗体,并通过Western blot和免疫组化验证其特异性。该抗体成功应用于肝组织样本中NR0B2的表达定位,证实其在代谢相关疾病研究中的实用性。

2. **文献名称**:*"NR0B2 Antibody-Based Detection of Transcriptional Repression Activity in Bile Acid Homeostasis"*

**作者**:Lee SS, et al.

**摘要**:利用NR0B2抗体进行染色质免疫沉淀(ChIP)和共免疫沉淀实验,揭示了NR0B2通过与FXR(法尼醇X受体)相互作用抑制胆汁酸合成基因的分子机制,为代谢调控提供新见解。

3. **文献名称**:*"Validation of NR0B2 as a Therapeutic Target in Obesity-Related Metabolic Dysfunction via Antibody-Mediated Inhibition"*

**作者**:Thompson JR, et al.

**摘要**:研究通过阻断性NR0B2抗体在小鼠模型中抑制其功能,发现NR0B2活性降低可改善胰岛素敏感性和脂质代谢紊乱,提示其作为代谢性疾病治疗靶点的潜力。

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**注**:以上文献为示例,实际引用需核对具体论文信息。如需真实文献,建议通过PubMed或Google Scholar检索关键词“NR0B2 antibody”或“SHP antibody”获取最新研究。

       

背景信息

The nuclear receptor subfamily 0 group B member 2 (NR0B2), also known as Small Heterodimer Partner (SHP), is an atypical orphan nuclear receptor lacking a DNA-binding domain. It functions as a transcriptional regulator by interacting with other nuclear receptors (e.g., LRH-1. FXR, HNF4α) and repressing their activity. NR0B2 plays a critical role in metabolic pathways, including bile acid synthesis, cholesterol homeostasis, glucose metabolism, and hepatic lipogenesis. Its dysregulation is associated with metabolic disorders, liver diseases, and cancer.

NR0B2 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore NR0B2's regulatory mechanisms in tissues, particularly the liver and intestines. Researchers also employ these antibodies to investigate its role in diseases such as non-alcoholic fatty liver disease (NAFLD), diabetes, and obesity.

Commercially available NR0B2 antibodies are typically raised against specific epitopes of human or mouse NR0B2 proteins. Validation includes reactivity checks across species, specificity confirmation via knockout controls, and application-specific performance testing. These antibodies support both basic research and therapeutic development, as NR0B2 is considered a potential drug target for metabolic syndrome and cholestatic liver disorders.

       
关键字: NR0B2抗体;NR0B2;NR0B2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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