TPM1抗体,Rabbit Polyclonal TPM1 Antibody
  • TPM1抗体,Rabbit Polyclonal TPM1 Antibody
  • TPM1抗体,Rabbit Polyclonal TPM1 Antibody
  • TPM1抗体,Rabbit Polyclonal TPM1 Antibody

TPM1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
QQ交谈 微信洽谈

产品详情

中文名称:TPM1抗体英文名称:Rabbit Polyclonal TPM1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3680 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TPM1
2025-05-13 TPM1抗体 Rabbit Polyclonal TPM1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3680 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCMH3; TMSA; CMD1Y; C15orf13; HTM-alpha
WB Predicted band size33 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human TPM1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane: Mouse heart tissue, Primary antibody: P07687(TPM1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07687(TPM1 Antibody) at dilution 1/80. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07687(TPM1 Antibody) at dilution 1/80. (Original magnification: ×200)    


           

参考文献

以下是关于TPM1抗体的3篇示例文献(注:内容为模拟生成,仅供参考,实际文献请通过学术数据库查询):

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1. **文献名称**: "Autoantibodies against TPM1 in autoimmune myocarditis: Clinical correlates and diagnostic utility"

**作者**: Müller, A. et al.

**摘要**: 本研究探讨了自身免疫性心肌炎患者血清中TPM1抗体的存在及其临床意义。通过蛋白质印迹和ELISA检测发现,TPM1抗体阳性率显著高于健康对照组,且与左心室功能障碍相关,提示其可能作为疾病活动性的生物标志物。

2. **文献名称**: "TPM1 expression in triple-negative breast cancer: Immunohistochemical analysis and prognostic implications"

**作者**: Chen, L. et al.

**摘要**: 利用TPM1特异性抗体对三阴性乳腺癌组织进行免疫组化分析,发现TPM1低表达与肿瘤侵袭性及患者生存率下降相关,表明TPM1可能作为潜在的预后指标和治疗靶点。

3. **文献名称**: "Proteomic identification of TPM1 as an autoantigen in systemic sclerosis-associated pulmonary fibrosis"

**作者**: Tanaka, K. et al.

**摘要**: 通过蛋白质组学筛选发现,系统性硬化症合并肺纤维化患者血清中TPM1自身抗体水平升高,进一步验证其与疾病严重程度的相关性,为探索发病机制提供了新方向。

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如需真实文献,建议使用PubMed或Google Scholar检索关键词(如“TPM1 antibody biomarker”“TPM1 autoantibody disease”),并筛选近年发表的论文。

       

背景信息

TPM1 (Tropomyosin 1) antibodies are tools used to study the expression and function of TPM1. a key protein in the tropomyosin family. Tropomyosins are actin-binding proteins that regulate cytoskeletal dynamics and muscle contraction by stabilizing actin filaments and modulating their interaction with myosin. The TPM1 gene undergoes alternative splicing, producing multiple isoforms with distinct roles in different cell types. For example, high-molecular-weight isoforms (e.g., TPM1α/β) are critical in muscle cells, while low-molecular-weight isoforms are involved in non-muscle cellular processes like cell motility and division.

TPM1 antibodies are widely used in research to investigate tissue-specific expression, subcellular localization, and post-translational modifications of TPM1. They are essential in studying pathologies linked to TPM1 dysregulation, such as cancer (e.g., breast, gastric, and prostate cancers), where TPM1 often acts as a tumor suppressor. Loss of TPM1 expression is associated with increased metastasis and poor prognosis. Additionally, TPM1 mutations are implicated in inherited cardiomyopathies, making these antibodies valuable in cardiovascular research.

These antibodies are typically validated via Western blotting, immunohistochemistry, or immunofluorescence. Researchers must select isoform-specific antibodies due to the high homology among tropomyosin family members. Understanding TPM1's role in cellular mechanics and disease mechanisms continues to drive the development and application of TPM1 antibodies in both basic and translational studies.

       
关键字: TPM1抗体;TPM1;TPM1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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