ACTRT1 (actin-related protein T1) is a less-characterized member of the actin-related protein (Arp) family, which shares structural similarities with conventional actin but performs specialized cellular functions. It is implicated in regulating cytoskeletal dynamics, intracellular trafficking, and chromatin remodeling. ACTRT1 is thought to interact with other Arp complex components to modulate actin filament organization, influencing cell motility, division, and signaling pathways. Its expression has been detected in various tissues, with emerging research suggesting potential roles in cancer progression, neuronal development, and reproductive biology.
ACTRT1 antibodies are immunodetection tools developed to study the protein’s expression, localization, and interactions. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to map ACTRT1 distribution in cellular compartments or tissue samples. Recent studies have explored ACTRT1’s overexpression in certain cancers, linking it to tumor invasiveness and metastasis, which positions ACTRT1 antibodies as potential diagnostic or prognostic biomarkers. However, the protein’s functional mechanisms remain under investigation, partly due to its low abundance and overlapping roles with other Arps. Researchers emphasize antibody validation using knockout controls to ensure specificity, as cross-reactivity with homologous proteins is a common challenge. Ongoing work aims to elucidate ACTRT1’s precise contributions to cellular processes and disease contexts, leveraging these antibodies for mechanistic and translational studies.