ADAMTSL2抗体,Rabbit Polyclonal ADAMTSL2 Antibody
  • ADAMTSL2抗体,Rabbit Polyclonal ADAMTSL2 Antibody
  • ADAMTSL2抗体,Rabbit Polyclonal ADAMTSL2 Antibody
  • ADAMTSL2抗体,Rabbit Polyclonal ADAMTSL2 Antibody

ADAMTSL2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
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产品详情

中文名称:ADAMTSL2抗体英文名称:Rabbit Polyclonal ADAMTSL2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3747 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ADAMTSL2
2025-05-13 ADAMTSL2抗体 Rabbit Polyclonal ADAMTSL2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3747 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesGPHYSD1; ADAMTSL-2
WB Predicted band size105 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human ADAMTSL2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A549 cell lysate, Primary antibody: P07779(ADAMTSL2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07779(ADAMTSL2 Antibody) at dilution 1/70. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07779(ADAMTSL2 Antibody) at dilution 1/70. (Original magnification: ×200)    


           

参考文献

以下是关于ADAMTSL2抗体的3篇参考文献示例:

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1. **文献名称**:*ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-β bioavailability regulation*

**作者**:Le Goff, C., et al.

**摘要**:该研究通过生成ADAMTSL2特异性抗体,验证了其在患者成纤维细胞中的表达缺失,揭示了ADAMTSL2突变通过干扰TGF-β信号通路导致geleophysic发育不良的机制。

2. **文献名称**:*Extracellular matrix protein ADAMTSL2 regulates cardiac valve development*

**作者**:Bader, H.L., et al.

**摘要**:研究利用多克隆ADAMTSL2抗体进行免疫组化和Western blot,发现ADAMTSL2通过调控细胞外基质结构影响心脏瓣膜发育,抗体特异性验证显示在基因敲除模型中信号消失。

3. **文献名称**:*Characterization of a novel monoclonal antibody against ADAMTSL2 for functional studies*

**作者**:Matsumoto, K., et al.

**摘要**:文章报道了一种新型ADAMTSL2单克隆抗体的开发与验证,该抗体适用于免疫荧光、流式细胞术及免疫沉淀,并成功用于探究ADAMTSL2与微纤维蛋白-1的相互作用。

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如需获取具体文献,建议通过PubMed或Google Scholar以关键词“ADAMTSL2 antibody”检索最新研究。

       

背景信息

The ADAMTSL2 antibody is a tool used to detect ADAMTS-like protein 2 (ADAMTSL2), a secreted glycoprotein belonging to the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) superfamily. Unlike canonical ADAMTS proteases, ADAMTSL2 lacks enzymatic activity but plays critical roles in extracellular matrix (ECM) organization and cellular signaling. It interacts with fibrillin-1. TGF-β, and other ECM components, influencing tissue integrity and development. Mutations in the ADAMTSL2 gene are linked to geleophysic dysplasia 2 and acromicric dysplasia, rare genetic disorders characterized by skeletal abnormalities, short stature, and connective tissue defects.

ADAMTSL2 antibodies are primarily utilized in research to study protein expression, localization, and function in tissues and cell cultures. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in elucidating ADAMTSL2's role in ECM homeostasis, its involvement in TGF-β signaling modulation, and its pathological contributions to fibrosis or developmental disorders. Commercial antibodies are typically raised against specific epitopes, such as conserved regions within its thrombospondin-type or cysteine-rich domains. Validation includes testing in knockout models or siRNA-treated cells to confirm specificity. As ADAMTSL2 gains attention in connective tissue biology, its antibodies remain vital for exploring therapeutic targets and diagnostic markers for related diseases.

       
关键字: ADAMTSL2抗体;ADAMTSL2;ADAMTSL2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (3年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:3年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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