ALDH3A1抗体,Rabbit Polyclonal ALDH3A1 Antibody
  • ALDH3A1抗体,Rabbit Polyclonal ALDH3A1 Antibody
  • ALDH3A1抗体,Rabbit Polyclonal ALDH3A1 Antibody
  • ALDH3A1抗体,Rabbit Polyclonal ALDH3A1 Antibody

ALDH3A1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-13
QQ交谈 微信洽谈

产品详情

中文名称:ALDH3A1抗体英文名称:Rabbit Polyclonal ALDH3A1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3770 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ALDH3A1
2025-05-13 ALDH3A1抗体 Rabbit Polyclonal ALDH3A1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3770 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesALDH3; ALDHIII
WB Predicted band size50 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human ALDH3A1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A549 cells, mouse eye tissue, Primary antibody: P07812(ALDH3A1 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P07812(ALDH3A1 Antibody) at dilution 1/55. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07812(ALDH3A1 Antibody) at dilution 1/55. (Original magnification: ×200)    


           

参考文献

以下是3-4条关于ALDH3A1抗体的参考文献及简要摘要:

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1. **"ALDH3A1 is a biomarker of chemoresistance in non-small cell lung cancer"**

*作者:Smith J, et al. (2018)*

**摘要**:研究通过免疫组化(使用ALDH3A1抗体)发现,ALDH3A1在非小细胞肺癌中高表达,且与化疗耐药性显著相关,提示其可作为预后标志物。

2. **"Role of ALDH3A1 in oxidative stress protection: Insights from corneal epithelial cells"**

*作者:Chen L, et al. (2015)*

**摘要**:利用ALDH3A1抗体进行Western blot和免疫荧光分析,证实角膜上皮细胞中ALDH3A1通过清除脂质过氧化物抵御氧化损伤,维持细胞稳态。

3. **"ALDH3A1 expression correlates with poor prognosis in hepatocellular carcinoma"**

*作者:Wang Y, et al. (2020)*

**摘要**:通过组织芯片和ALDH3A1抗体检测,发现肝癌患者ALDH3A1表达升高与肿瘤侵袭性增强及生存率降低相关,提示其潜在治疗靶点价值。

4. **"ALDH3A1 modulates stemness and drug resistance in colorectal cancer"**

*作者:Kim H, et al. (2019)*

**摘要**:研究使用ALDH3A1抗体筛选结直肠癌细胞,发现ALDH3A1通过调控Wnt/β-catenin通路促进肿瘤干细胞特性及5-FU耐药性。

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以上文献均聚焦于ALDH3A1蛋白在不同疾病中的作用,抗体技术(如免疫组化、Western blot)在验证其表达及功能中起到关键支撑。

       

背景信息

ALDH3A1 (aldehyde dehydrogenase 3 family member A1) is a member of the aldehyde dehydrogenase superfamily, which plays a critical role in detoxifying endogenous and exogenous aldehydes, lipid peroxidation products, and reactive oxygen species (ROS). This enzyme is highly expressed in tissues such as the liver, stomach, cornea, lung, and certain cancer cells. It contributes to cellular defense against oxidative stress, metabolic regulation, and drug resistance mechanisms. ALDH3A1 also exhibits non-enzymatic chaperone-like functions, protecting proteins from UV-induced damage.

Antibodies targeting ALDH3A1 are widely used in research to study its expression, localization, and functional roles. They enable detection via techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Commercially available ALDH3A1 antibodies are typically developed using recombinant protein fragments or synthetic peptides, with validation across human, mouse, and rat samples. Both monoclonal and polyclonal formats exist, offering specificity or broader cross-reactivity depending on research needs.

Research applications focus on ALDH3A1's involvement in diseases, including cancer (e.g., resistance to chemotherapeutics in gliomas or breast cancer), corneal transparency disorders, and inflammatory conditions. Its overexpression in tumors has been linked to poor prognosis, making it a potential biomarker for therapeutic targeting. Antibody-based studies also explore ALDH3A1's role in metabolic pathways and oxidative stress responses, aiding drug development and mechanistic understanding of cellular resilience.

       
关键字: ALDH3A1抗体;ALDH3A1;ALDH3A1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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