INTS10抗体

The INTS10 antibody is designed to target the Integrator Complex Subunit 10 (INTS10), a component of the Integrator complex, a multi-protein assembly critical for RNA polymerase II (RNAPII)-mediated transcription regulation. The Integrator complex, comprising at least 14 subunits (INTS1-14), plays diverse roles in RNA processing, including 3' end cleavage of small nuclear RNAs (snRNAs) and enhancer RNAs (eRNAs), as well as transcriptional termination and pause release. INTS10. as a core subunit, contributes to the structural integrity and enzymatic activity of the complex, particularly in facilitating interactions with RNAPII and other transcriptional regulators. Dysregulation of Integrator subunits has been linked to developmental disorders and cancers, underscoring their biological significance. The INTS10 antibody is widely utilized in research to investigate the complex's molecular mechanisms, protein localization, and expression profiles via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Studies employing this antibody have shed light on INTS10's role in transcriptional elongation, RNA processing, and its potential involvement in disease pathways. Its specificity and reliability make it a valuable tool for dissecting the Integrator complex's functional dynamics in cellular and pathological contexts.