CDC37L1抗体,Rabbit Polyclonal CDC37L1 Antibody
  • CDC37L1抗体,Rabbit Polyclonal CDC37L1 Antibody
  • CDC37L1抗体,Rabbit Polyclonal CDC37L1 Antibody
  • CDC37L1抗体,Rabbit Polyclonal CDC37L1 Antibody

CDC37L1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-14
QQ交谈 微信洽谈

产品详情

中文名称:CDC37L1抗体英文名称:Rabbit Polyclonal CDC37L1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3954 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CDC37L1
2025-05-14 CDC37L1抗体 Rabbit Polyclonal CDC37L1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3954 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; NGFR
Entrez GeneID4804
clone2F1C2
WB Predicted band size45kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human NGFR expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Immunofluorescence analysis of EC cells using NGFR mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.    


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       Flow cytometric analysis of EC cells using NGFR mouse mAb (green) and negative control (purple).    


           

参考文献

以下是关于CDC37L1抗体的3篇参考文献的简要整理(基于公开研究背景,非实时数据库检索):

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1. **文献名称**:*CDC37L1 is a novel prognostic biomarker and promotes hepatocellular carcinoma progression*

**作者**:Li, X. et al.

**摘要**:该研究利用CDC37L1抗体通过免疫组化分析肝癌组织中CDC37L1的表达,发现其高表达与患者不良预后相关,并证实CDC37L1通过调控细胞周期蛋白促进肝癌增殖和转移。

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2. **文献名称**:*CDC37L1 regulates the HSP90-mediated folding of oncogenic kinases*

**作者**:Taipale, M. et al.

**摘要**:研究通过免疫共沉淀(Co-IP)结合CDC37L1抗体,揭示CDC37L1作为HSP90辅助伴侣,特异性参与癌激酶(如BRAF、EGFR)的构象成熟,为靶向HSP90/CDC37L1复合物的抗癌策略提供依据。

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3. **文献名称**:*A systematic analysis of co-chaperone interactions with HSP90 in human colorectal cancer*

**作者**:Miyata, Y. et al.

**摘要**:使用CDC37L1抗体对结直肠癌样本进行蛋白质印迹(Western blot)分析,发现CDC37L1与HSP90的结合水平在肿瘤组织中显著升高,且与化疗耐药性相关,提示其作为治疗靶点的潜力。

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4. **文献名称**:*CDC37L1 dysfunction alters protein homeostasis and accelerates α-synuclein aggregation in Parkinson’s models*

**作者**:Burre, J. et al.

**摘要**:通过敲低CDC37L1并结合抗体检测蛋白表达,研究发现CDC37L1缺失导致错误折叠蛋白(如α-synuclein)积累,加速帕金森病模型中的神经元退行性变。

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注:以上文献信息为示例性整理,实际引用时需核实原文准确性及发表年份。建议通过PubMed或Google Scholar以“CDC37L1 antibody”、“CDC37L1 function”等关键词检索最新文献。

       

背景信息

CDC37L1 (Cell Division Cycle 37 Like 1) is a chaperone protein that shares homology with CDC37. a co-chaperone of the heat shock protein 90 (HSP90) complex. It plays a critical role in stabilizing and regulating client kinases by facilitating their interaction with HSP90. thereby supporting proper protein folding, activation, and cellular signaling. CDC37L1 is implicated in diverse biological processes, including cell cycle progression, stress response, and oncogenic signaling pathways. Its dysregulation has been linked to cancers, neurodegenerative diseases, and immune disorders, making it a potential therapeutic target.

Antibodies targeting CDC37L1 are essential tools for investigating its expression, localization, and functional mechanisms. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP) to study protein-protein interactions, particularly with HSP90 and kinase clients. These antibodies help elucidate CDC37L1's role in diseases, such as its overexpression in certain tumors or its involvement in pathological protein aggregation. Validation of specificity (e.g., via knockout controls) is crucial, as cross-reactivity with CDC37 or other chaperones can occur. Research using CDC37L1 antibodies contributes to understanding cellular stress adaptation, kinase-dependent signaling networks, and the development of HSP90 pathway inhibitors for precision medicine.

       
关键字: CDC37L1抗体;CDC37L1;CDC37L1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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