PPIB抗体,Rabbit Polyclonal PPIB Antibody
  • PPIB抗体,Rabbit Polyclonal PPIB Antibody
  • PPIB抗体,Rabbit Polyclonal PPIB Antibody

PPIB抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-15
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产品详情

中文名称:PPIB抗体英文名称:Rabbit Polyclonal PPIB Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3988 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PPIB
2025-05-15 PPIB抗体 Rabbit Polyclonal PPIB Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3988 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesOI9; CYPB; SCYLP; CYP-S1
WB Predicted band size24 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human PPIB
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human fetal liver tissue, 293T cells, human liver cancer tissue, hela cells, Primary antibody: P08192(PPIB Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P08192(PPIB Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08192(PPIB Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于PPIB抗体的3篇虚构参考文献示例,内容基于常见研究方向概括:

1. **文献名称**: *Cyclophilin B (PPIB) Antibody Validation for Protein Folding Studies in Mammalian Cells*

**作者**: Smith A, et al.

**摘要**: 本研究验证了一种高特异性PPIB抗体在HeLa细胞中的应用,通过免疫沉淀和Western blot证实PPIB与内质网伴侣蛋白的相互作用,揭示其在胶原蛋白折叠中的关键作用,并发现PPIB缺失导致细胞外基质异常。

2. **文献名称**: *PPIB Overexpression as a Prognostic Marker in Glioblastoma: An Immunohistochemical Analysis*

**作者**: Chen L, et al.

**摘要**: 利用PPIB抗体对120例胶质母细胞瘤组织进行免疫组化分析,发现PPIB高表达与患者总生存期缩短显著相关,提示其可能作为潜在治疗靶点和预后标志物。

3. **文献名称**: *Comparative Evaluation of Commercial Anti-PPIB Antibodies in Neurodegenerative Disease Models*

**作者**: González R, et al.

**摘要**: 系统评估5种商品化PPIB抗体在小鼠阿尔茨海默病模型中的性能,发现抗体Clone 3F8在冰冻脑组织切片中表现最优,成功检测到tau蛋白异常聚集相关的PPIB表达上调。

(注:以上为模拟文献,实际引用需以真实出版物为准。)

       

背景信息

**Background of PPIB Antibody**

The PPIB (Peptidyl-Prolyl cis-trans Isomerase B) antibody is a tool used to detect and study the PPIB protein, a member of the cyclophilin family of immunophilins. PPIB, also known as cyclophilin B, is a 22 kDa endoplasmic reticulum (ER)-resident protein that exhibits peptidyl-prolyl isomerase (PPIase) activity, facilitating proper protein folding by catalyzing the cis-trans isomerization of proline residues. It plays a critical role in collagen biosynthesis by interacting with prolyl hydroxylase and serving as a chaperone for procollagen.

PPIB is implicated in various physiological and pathological processes, including inflammation, viral replication, and cancer progression. Its overexpression has been observed in certain cancers, such as hepatocellular carcinoma and breast cancer, where it may promote tumor cell survival and metastasis. Additionally, PPIB interacts with the ER stress response pathway and modulates calcium signaling.

The PPIB antibody is widely utilized in research applications, including Western blotting, immunohistochemistry, and immunofluorescence, to investigate PPIB expression, localization, and function. It is also employed in studies exploring its role in diseases and potential therapeutic targeting. Commercially available PPIB antibodies are typically raised in rabbits or mice, validated for specificity against human, mouse, or rat PPIB isoforms. Understanding PPIB's molecular mechanisms through antibody-based assays contributes to insights into collagen-related disorders, cancer biology, and drug development.

       


关键字: PPIB抗体;PPIB;PPIB Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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