CST6抗体,Rabbit Polyclonal CST6 Antibody
  • CST6抗体,Rabbit Polyclonal CST6 Antibody
  • CST6抗体,Rabbit Polyclonal CST6 Antibody
  • CST6抗体,Rabbit Polyclonal CST6 Antibody

CST6抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-14
QQ交谈 微信洽谈

产品详情

中文名称:CST6抗体英文名称:Rabbit Polyclonal CST6 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4000 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CST6
2025-05-14 CST6抗体 Rabbit Polyclonal CST6 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4000 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human CST6
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P08208(CST6 Antibody) at dilution 1/70. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08208(CST6 Antibody) at dilution 1/70. (Original magnification: ×200)    


           

参考文献

以下是关于CST6抗体的示例参考文献(内容为模拟概括,建议通过学术数据库核实最新研究):

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1. **文献名称**:*Cystatin 6 (CST6) as a biomarker in serous ovarian carcinoma: Immunohistochemical analysis*

**作者**:Zhang Y, et al. (2017)

**摘要**:研究通过CST6抗体进行免疫组化分析,发现CST6在卵巢癌组织中高表达,且与患者预后不良相关,提示其可能作为潜在治疗靶点。

2. **文献名称**:*Development of a monoclonal antibody against CST6 and its application in breast cancer progression*

**作者**:Wang L, et al. (2015)

**摘要**:开发了针对CST6的单克隆抗体,实验表明抑制CST6可减少乳腺癌细胞侵袭,抗体为研究CST6在肿瘤转移中的作用提供了工具。

3. **文献名称**:*Epigenetic silencing of CST6 in oral squamous cell carcinoma: Validation by antibody-based assays*

**作者**:Chen H, et al. (2020)

**摘要**:利用CST6抗体验证口腔鳞癌中CST6的表观遗传沉默,发现其启动子甲基化导致表达下调,与肿瘤分化程度相关。

4. **文献名称**:*CST6 as a prognostic marker in head and neck cancer: Correlation studies using antibody-mediated detection*

**作者**:Liu X, et al. (2018)

**摘要**:通过抗体检测头颈癌患者组织中CST6水平,发现低表达与淋巴结转移和生存率下降显著相关,支持其作为预后标志物。

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**备注**:以上内容为示例,实际文献需通过PubMed、Google Scholar或Web of Science等平台检索关键词(如“CST6 antibody”“Cystatin 6 cancer”)获取最新研究。

       

背景信息

The cystatin superfamily comprises cysteine protease inhibitors involved in regulating proteolytic activity. Cystatin 6 (CST6), a member of the type 1 cystatin family, is encoded by the *CST6* gene and functions as an extracellular inhibitor of cathepsins, enzymes linked to tissue remodeling, inflammation, and cancer progression. Unlike other cystatins, CST6 contains a unique signal peptide for secretion and a conserved cystatin domain, enabling extracellular protease regulation.

Research highlights CST6's dual role in cancer biology. It exhibits tumor-suppressive properties in some contexts by inhibiting cathepsin-mediated invasion and metastasis, notably in breast and ovarian cancers. However, its overexpression in other malignancies, such as oral squamous cell carcinoma, correlates with poor prognosis, suggesting context-dependent functions. CST6 is also implicated in skin barrier formation and immunological processes.

CST6 antibodies are critical tools for detecting CST6 expression in tissues or biofluids via immunohistochemistry, Western blotting, or ELISA. These antibodies aid in studying CST6's role in disease mechanisms, validating its potential as a diagnostic or prognostic biomarker, and exploring therapeutic strategies targeting protease pathways. Commercial CST6 antibodies are typically validated for specificity against recombinant or endogenous proteins, though variability in experimental conditions requires careful optimization. Ongoing research seeks to clarify CST6's regulatory networks and clinical relevance across pathologies.

       
关键字: CST6抗体;CST6;CST6 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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