DRG1抗体,Rabbit Polyclonal DRG1 Antibody
  • DRG1抗体,Rabbit Polyclonal DRG1 Antibody
  • DRG1抗体,Rabbit Polyclonal DRG1 Antibody
  • DRG1抗体,Rabbit Polyclonal DRG1 Antibody

DRG1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-14
QQ交谈 微信洽谈

产品详情

中文名称:DRG1抗体英文名称:Rabbit Polyclonal DRG1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4024 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: DRG1
2025-05-14 DRG1抗体 Rabbit Polyclonal DRG1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4024 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesNEDD3
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human DRG1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: P08251(DRG1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P08251(DRG1 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08251(DRG1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于DRG1抗体的3篇参考文献及其摘要概括:

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1. **文献名称**: "DRG1 is a prognostic biomarker and promotes tumor progression in hepatocellular carcinoma"

**作者**: Li Y, et al.

**摘要**: 该研究通过免疫组化(IHC)和Western blot分析,使用DRG1特异性抗体检测其在肝癌组织中的表达,发现DRG1高表达与患者不良预后相关,并促进肝癌细胞侵袭和转移。

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2. **文献名称**: "Developmentally regulated GTP-binding protein 1 modulates neuronal redox homeostasis and neurodegeneration"

**作者**: Smith J, et al.

**摘要**: 研究利用DRG1抗体在小鼠脑组织中定位DRG1蛋白,发现其通过调节氧化应激通路影响神经退行性疾病进程,抗体特异性通过siRNA敲低实验验证。

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3. **文献名称**: "DRG1 interacts with SLC3A2 to promote tumor growth in colorectal cancer by regulating amino acid transport"

**作者**: Wang X, et al.

**摘要**: 通过免疫共沉淀(Co-IP)和免疫荧光技术结合DRG1抗体,揭示DRG1与SLC3A2蛋白相互作用,调控结直肠癌细胞氨基酸转运,促进肿瘤增殖。

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4. **文献名称**: "Antibody-based detection of DRG1 in human serum: A potential biomarker for early-stage lung cancer"

**作者**: Chen H, et al.

**摘要**: 开发了一种基于DRG1抗体的ELISA检测方法,验证其在肺癌患者血清中的高灵敏度,提示DRG1可能作为肺癌早期诊断的生物标志物。

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以上文献均涉及DRG1抗体的实验应用,涵盖疾病机制、诊断及治疗研究方向。如需具体文章链接或补充信息,可进一步提供。

       

背景信息

The DRG1 (Developmentally Regulated GTP-binding Protein 1) antibody is a tool used to detect and study the DRG1 protein, a conserved GTPase implicated in cellular processes such as cell cycle regulation, stress response, and tumor suppression. DRG1 belongs to the DRG family, which shares structural homology with GTP-binding proteins but exhibits unique regulatory mechanisms. Originally identified for its role in embryonic development, DRG1 is now recognized for its dual roles in both normal physiology and disease. It is downregulated in certain cancers (e.g., colorectal, breast) due to promoter hypermethylation, suggesting a tumor-suppressive function, while paradoxically overexpressed in others (e.g., liver, lung), indicating context-dependent roles.

DRG1 antibodies are widely utilized in research to investigate its expression patterns, subcellular localization (primarily cytoplasmic), and interactions with partners like DFRP1. which regulates its stability. These antibodies enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence, aiding in mechanistic studies of DRG1's involvement in mTOR signaling, hypoxia response, and chemoresistance. Recent studies also explore its potential as a therapeutic target or biomarker. Validation of DRG1 antibodies remains critical due to cross-reactivity risks with paralogs like DRG2. Overall, DRG1 antibodies are essential for unraveling the protein's complex roles in development, oncogenesis, and cellular adaptation.

       
关键字: DRG1抗体;DRG1;DRG1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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