SH3BGRL抗体

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09815(SH3BGRL Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

SH3BGRL (SH3 domain-binding glutamic acid-rich protein-like) is a small, evolutionarily conserved protein encoded by the *SH3BGRL* gene. It belongs to the SH3BGR family, characterized by a central glutamic acid-rich region and a C-terminal SH3-binding motif. SH3BGRL interacts with SH3 domain-containing proteins, suggesting roles in signal transduction, protein-protein interactions, and cellular processes such as differentiation, apoptosis, and cytoskeletal organization. While its exact biological functions remain incompletely understood, SH3BGRL has been implicated in cancer, cardiovascular diseases, and metabolic disorders, with studies highlighting both tumor-suppressive and oncogenic potentials depending on context.

Antibodies targeting SH3BGRL are essential tools for investigating its expression, localization, and molecular mechanisms. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using SH3BGRL antibodies has revealed its differential expression in tissues such as heart, liver, and skeletal muscle, as well as altered levels in tumors compared to normal tissues. Some studies propose SH3BGRL as a biomarker for disease progression or therapeutic response. However, inconsistencies in reported roles (e.g., promoting or inhibiting cell migration) underscore the need for further validation of antibody specificity and functional studies. Current efforts focus on clarifying SH3BGRL’s interactions with signaling pathways like Ras/MAPK or PI3K/AKT, potentially unlocking therapeutic applications.