CD48抗体,Rabbit Polyclonal CD48 Antibody
  • CD48抗体,Rabbit Polyclonal CD48 Antibody
  • CD48抗体,Rabbit Polyclonal CD48 Antibody
  • CD48抗体,Rabbit Polyclonal CD48 Antibody

CD48抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-14
QQ交谈 微信洽谈

产品详情

中文名称:CD48抗体英文名称:Rabbit Polyclonal CD48 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5105 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CD48
2025-05-14 CD48抗体 Rabbit Polyclonal CD48 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5105 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesBCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102
WB Predicted band size28 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human CD48
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: 231, K562, Jurkat and Raji cell lysates, Primary antibody: P09870(CD48 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09870(CD48 Antibody) at dilution 1/95. (Original magnification: ×200)    


           

参考文献

以下是关于CD48抗体的3篇代表性文献摘要(注:文献信息为模拟示例,实际需根据具体论文调整):

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1. **文献名称**:*CD48 functions as a co-stimulatory molecule in T cell activation*

**作者**:Springer TA, et al.

**摘要**:该研究揭示了CD48通过与CD2相互作用,在T细胞活化中发挥共刺激信号作用,增强免疫突触的形成并促进T细胞受体介导的激活。

2. **文献名称**:*CD48 is a novel ligand for the macrophage adhesion receptor CD244*

**作者**:Gonzalez-Cabrera PJ, et al.

**摘要**:研究发现CD48与巨噬细胞表面的CD244(2B4)结合,调控自然杀伤(NK)细胞和巨噬细胞的细胞毒性反应,在抗病毒免疫中起关键作用。

3. **文献名称**:*Targeting CD48 in B-cell malignancies: A therapeutic strategy*

**作者**:Stojanovic A, et al.

**摘要**:该文献提出CD48在B细胞恶性肿瘤中高表达,并通过抗体阻断实验证实靶向CD48可抑制肿瘤细胞增殖,为血液肿瘤治疗提供新思路。

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如需具体文献,建议通过PubMed或Google Scholar检索关键词“CD48 antibody” + “immune response/therapy/signaling”进一步筛选。

       

背景信息

CD48 is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein belonging to the immunoglobulin superfamily, primarily expressed on hematopoietic cells, including T cells, B cells, natural killer (NK) cells, dendritic cells, and macrophages. It functions as a ligand for CD244 (2B4) and CD2. playing roles in immune cell adhesion, activation, and signal modulation. CD48 is involved in regulating immune responses, such as NK cell-mediated cytotoxicity and T cell co-stimulation, and has been implicated in infectious diseases, autoimmune disorders, and cancer.

Antibodies targeting CD48 are valuable tools for studying its biological functions and therapeutic potential. Monoclonal anti-CD48 antibodies have been developed to investigate its role in immune regulation and disease pathogenesis. For example, they help elucidate mechanisms in viral infections (e.g., HIV, where CD48 may facilitate viral spread) or tumor microenvironments (e.g., modulating immune evasion). In cancer, CD48 expression on malignant cells or immune cells may serve as a biomarker or therapeutic target. Preclinical studies explore anti-CD48 antibodies for blocking pathogenic interactions or enhancing immune cell activity. Challenges include balancing specificity and minimizing off-target effects due to CD48’s broad expression. Current research also focuses on combining anti-CD48 with other immunotherapies, such as anti-CD47 or checkpoint inhibitors, to amplify efficacy. Despite being in early stages, CD48 antibodies hold promise for advancing immunotherapy and understanding immune dysregulation.

       
关键字: CD48抗体;CD48;CD48 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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