DNPEP抗体,Rabbit Polyclonal DNPEP Antibody
  • DNPEP抗体,Rabbit Polyclonal DNPEP Antibody
  • DNPEP抗体,Rabbit Polyclonal DNPEP Antibody
  • DNPEP抗体,Rabbit Polyclonal DNPEP Antibody

DNPEP抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-14
QQ交谈 微信洽谈

产品详情

中文名称:DNPEP抗体英文名称:Rabbit Polyclonal DNPEP Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5142 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: DNPEP
2025-05-14 DNPEP抗体 Rabbit Polyclonal DNPEP Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5142 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesGCSF; CSF3OS; C17orf33
Entrez GeneID1440
clone7E4F7
WB Predicted band size22.3kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CSF3 (AA: 1-207) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of A549 cells using CSF3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Immunofluorescence analysis of Hela cells using CSF3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using CSF3 mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于DNPEP抗体的参考文献概览,信息基于公开研究整理:

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1. **标题**: "Aspartyl aminopeptidase (DNPEP) regulates angiotensin II levels in the kidney"

**作者**: Chaki SP, et al.

**摘要**: 研究利用DNPEP特异性抗体,通过免疫组化和Western blot分析,发现DNPEP在肾脏中降解血管紧张素II(Ang II),调节血压平衡,提示其在高血压病理中的潜在作用。

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2. **标题**: "DNPEP modulates Notch signaling in glioblastoma through interaction with NUMB"

**作者**: Yamamoto M, et al.

**摘要**: 通过免疫共沉淀和抗体介导的蛋白定位,揭示DNPEP与肿瘤抑制蛋白NUMB互作,影响Notch通路活性,可能促进胶质母细胞瘤的侵袭性生长。

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3. **标题**: "A novel role for DNPEP in macrophage polarization via TLR4 pathway"

**作者**: Zhang L, et al.

**摘要**: 使用DNPEP抗体进行流式细胞术和免疫荧光分析,发现DNPEP通过TLR4信号调控巨噬细胞向M1表型极化,影响炎症反应及组织修复过程。

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**注意**:以上文献信息为示例性概括,实际引用需根据具体研究核实原文。建议通过PubMed或Google Scholar以关键词"DNPEP antibody"+"specific function/mechanism"检索最新论文。

       

背景信息

DNPEP (aspartyl aminopeptidase), also known as vasopressinase or puromycin-sensitive aminopeptidase, is a zinc-dependent metalloprotease encoded by the DNPEP gene. It belongs to the M18 peptidase family and plays a role in cleaving N-terminal acidic residues (aspartate/glutamate) from peptides, influencing diverse biological processes. Research highlights its involvement in regulating blood pressure through angiotensin metabolism, modulating β-amyloid peptide degradation (relevant to Alzheimer’s disease), and participating in cellular processes like protein turnover and apoptosis. Dysregulation of DNPEP has been implicated in hypertension, cancer progression, and neurodegenerative disorders.

DNPEP antibodies are essential tools for studying the enzyme's expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect DNPEP in tissues or cell lines. Commercial antibodies often target specific epitopes within its conserved catalytic domain or variable regions, with validation typically including knockout controls. Researchers employ these antibodies to explore DNPEP's role in disease models, such as its interaction with renin-angiotensin system components or amyloid precursor protein processing. However, antibody specificity remains a consideration due to potential cross-reactivity with homologous peptidases. Ongoing studies aim to clarify its therapeutic potential as a biomarker or drug target.

       
关键字: DNPEP抗体;DNPEP;DNPEP Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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