PYY抗体

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12145(PYY Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P12145(PYY Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

Peptide YY (PYY) is a 36-amino-acid gastrointestinal hormone produced by enteroendocrine L-cells in the distal gut, primarily in response to nutrient ingestion. It plays a critical role in regulating appetite, energy homeostasis, and digestive functions by acting on hypothalamic Y2 receptors to suppress hunger signals. PYY exists in two major forms: the full-length PYY₁–₃₆ and the truncated, biologically active PYY₃–₃₆, which accounts for most circulating PYY.

Antibodies targeting PYY are essential tools for studying its expression, secretion, and physiological roles. They enable quantitative detection (e.g., via ELISA or radioimmunoassay) and localization (e.g., immunohistochemistry) of PYY in tissues and biological fluids. Such antibodies are particularly valuable in metabolic research, including investigations into obesity, diabetes, and gut-brain signaling pathways. Specificity is a key challenge in developing PYY antibodies due to structural similarities with other peptides in the Y-family, such as neuropeptide Y (NPY) and pancreatic polypeptide (PP). Monoclonal and polyclonal antibodies are commonly generated using synthetic PYY fragments or purified native peptides as immunogens.

Recent advances in antibody engineering have improved affinity and cross-reactivity profiles, supporting translational applications like monitoring PYY dynamics in therapeutic interventions for metabolic disorders. However, variability in assay standardization remains a limitation in clinical research.