SIGLEC11抗体

The SIGLEC11 antibody targets SIGLEC11. a member of the sialic acid-binding immunoglobulin-type lectin (SIGLEC) family, which regulates immune responses through glycan-mediated signaling. Expressed predominantly in human macrophages and microglia, SIGLEC11 recognizes sialylated glycans on cell surfaces or secreted proteins, transmitting inhibitory signals to modulate phagocytosis, cytokine release, and inflammatory activity. It plays a role in maintaining immune tolerance, particularly in the central nervous system and placenta, by dampening excessive immune activation. Dysregulation of SIGLEC11 has been implicated in neurodegenerative diseases (e.g., Alzheimer’s) and pregnancy complications. The SIGLEC11 antibody is a critical tool for studying its expression, function, and ligand interactions in vitro and in vivo. Researchers use it to explore its potential as an immune checkpoint or therapeutic target, such as enhancing microglial clearance of amyloid-beta plaques or mitigating neuroinflammation. Its cross-reactivity with non-human primate homologs facilitates translational studies, though species-specific variations require careful validation.