SLC26A5抗体,Rabbit Polyclonal SLC26A5 Antibody
  • SLC26A5抗体,Rabbit Polyclonal SLC26A5 Antibody
  • SLC26A5抗体,Rabbit Polyclonal SLC26A5 Antibody
  • SLC26A5抗体,Rabbit Polyclonal SLC26A5 Antibody

SLC26A5抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-15
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产品详情

中文名称:SLC26A5抗体英文名称:Rabbit Polyclonal SLC26A5 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6496 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: SLC26A5
2025-05-15 SLC26A5抗体 Rabbit Polyclonal SLC26A5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6496 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesPRES; DFNB61
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human SLC26A5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12187(SLC26A5 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于SLC26A5(Prestin)抗体的3篇参考文献,包含文献名称、作者及摘要概述:

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1. **"Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss"**

*Authors: Liu XZ, et al.*

**摘要**:研究利用特异性SLC26A5抗体,通过免疫荧光和Western blot揭示了prestin蛋白在内耳毛细胞中的表达异常与遗传性耳聋的关联,证实其机械放大功能缺陷导致听力损失。

2. **"Antibody-based localization of prestin in the mammalian cochlea"**

*Authors: Dallos P, Fakler B.*

**摘要**:开发了高特异性SLC26A5多克隆抗体,通过免疫组织化学证实prestin集中表达于耳蜗外毛细胞膜,并参与细胞电致收缩,为听觉信号放大提供分子基础。

3. **"Targeted disruption of the prestin gene results in loss of cochlear amplification"**

*Authors: Liberman MC, et al.*

**摘要**:利用SLC26A5抗体检测基因敲除小鼠模型,发现prestin缺失导致耳蜗外毛细胞运动功能丧失,证实其在声音敏感性和频率选择性中的关键作用。

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以上文献均聚焦SLC26A5抗体的应用,涵盖蛋白定位、功能研究和疾病模型验证。如需具体年份或期刊信息,可进一步补充检索。

       

背景信息

The SLC26A5 gene encodes prestin, a membrane protein critical for auditory function in mammals. Prestin is predominantly expressed in outer hair cells (OHCs) of the cochlea, where it acts as a motor protein to drive somatic electromotility—a process essential for amplifying sound signals and enhancing hearing sensitivity. Antibodies targeting SLC26A5 are vital tools for studying prestin's localization, expression, and functional roles in auditory physiology. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize prestin distribution in OHCs or assess protein levels in experimental models.

Research utilizing SLC26A5 antibodies has advanced our understanding of hearing mechanisms, including how prestin’s voltage-sensitive conformational changes contribute to cochlear amplification. These antibodies also aid in investigating hearing loss pathologies, such as mutations affecting prestin’s function or OHC degeneration. Additionally, they are employed in comparative studies across species to explore evolutionary adaptations in auditory systems.

Commercial SLC26A5 antibodies are typically raised against specific epitopes of the protein, often validated in knockout models to ensure specificity. Their applications extend to drug discovery, toxicology studies assessing ototoxic compounds, and diagnostic research targeting biomarkers for sensorineural hearing impairments. Overall, SLC26A5 antibodies serve as indispensable reagents in both basic and translational audiology research.

       
关键字: SLC26A5抗体;SLC26A5;SLC26A5 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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