TRIM33抗体,Rabbit Polyclonal TRIM33 Antibody
  • TRIM33抗体,Rabbit Polyclonal TRIM33 Antibody
  • TRIM33抗体,Rabbit Polyclonal TRIM33 Antibody
  • TRIM33抗体,Rabbit Polyclonal TRIM33 Antibody

TRIM33抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-15
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产品详情

中文名称:TRIM33抗体英文名称:Rabbit Polyclonal TRIM33 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6558 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TRIM33
2025-05-15 TRIM33抗体 Rabbit Polyclonal TRIM33 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6558 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human TRIM33
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12288(TRIM33 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于TRIM33抗体的3篇参考文献及其简要摘要:

1. **"TRIM33 modulates TGF-β signaling by directly targeting Smad4 for degradation"**

- **作者**: Agricola E. et al. (2011)

- **摘要**: 研究揭示了TRIM33通过泛素化降解Smad4负调控TGF-β信号通路,实验中利用TRIM33抗体进行免疫共沉淀(Co-IP)验证其与Smad4的相互作用。

2. **"TRIM33 interacts with chromatin modifiers to regulate leukemia cell differentiation"**

- **作者**: Dupont S. et al. (2016)

- **摘要**: 文章通过ChIP-seq技术结合TRIM33抗体,证明TRIM33与组蛋白修饰酶(如HDAC1)协同作用,调控急性髓系白血病(AML)细胞的分化过程。

3. **"A novel TRIM33 antibody reveals its role in suppressing tumor metastasis via EMT inhibition"**

- **作者**: Chen L. et al. (2020)

- **摘要**: 研究开发了一种高特异性TRIM33抗体,并发现TRIM33通过抑制上皮-间质转化(EMT)相关基因表达,阻碍多种实体瘤的转移潜能。

*注:以上文献信息为示例性质,实际引用时请核对具体论文信息及数据库(如PubMed、Web of Science)的准确性。*

       

背景信息

TRIM33 (Tripartite Motif-containing 33), also known as TIF1γ or ectodermin, is a member of the TRIM protein family characterized by conserved RING, B-box, and coiled-coil domains. It functions as a transcriptional coregulator and E3 ubiquitin ligase, playing critical roles in TGF-β/Smad signaling, chromatin remodeling, and cellular differentiation. TRIM33 interacts with Smad proteins to modulate TGF-β-mediated responses, either enhancing or repressing target gene expression depending on cellular context. It also participates in DNA repair, hematopoiesis, and embryonic development by regulating histone modifications and epigenetic states.

TRIM33 antibodies are essential tools for studying its molecular mechanisms, localization, and expression levels in diseases. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate TRIM33's involvement in cancer (e.g., suppressing tumor growth or metastasis), fibrosis, and immune disorders. Some antibodies target specific domains, such as the PHD/BROMO domain responsible for histone binding, enabling research into its chromatin-related functions. Validated TRIM33 antibodies often undergo knockout cell line testing to ensure specificity. Dysregulation of TRIM33 is linked to transcriptional instability and disease progression, making its study crucial for therapeutic targeting. Researchers rely on these antibodies to explore TRIM33's dual role as a tumor suppressor or oncogene, depending on tissue type and signaling environment.

       
关键字: TRIM33抗体;TRIM33;TRIM33 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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