HUNK抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Western blot analysis using FCER1A mouse mAb against mouse kidney tissue lysate.    

  
  

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     Flow cytometric analysis of HEK293 cells using FCER1A mouse mAb (green) and negative control (red).    

  
  

**Background of HUNK Antibody**

HUNK (Hormonally Upregulated Neu-associated Kinase), also known as MAST4. is a serine/threonine kinase encoded by the *MAST4* gene. Initially identified in studies exploring hormone-responsive pathways, HUNK was found to be upregulated by estrogen and progesterone signaling in breast cancer models. It plays a role in cell proliferation, survival, and differentiation, with emerging evidence linking it to tissue development (e.g., mammary gland) and tumorigenesis.

HUNK antibodies are tools used to detect and study the expression, localization, and function of HUNK in biological systems. Research highlights its dual roles in cancer: it acts as an oncogene in certain contexts (e.g., promoting breast cancer metastasis and chemoresistance) but may suppress tumor growth in others (e.g., colorectal cancer). HUNK's interaction with pathways like mTOR, Wnt/β-catenin, and apoptosis regulators underscores its complex mechanistic involvement. Antibody-based studies (Western blot, immunohistochemistry) have been pivotal in mapping HUNK's tissue-specific expression and its correlation with clinical outcomes. Recent interest also explores HUNK's potential as a therapeutic target, particularly in hormone-driven cancers. Despite progress, its context-dependent functions and regulatory mechanisms remain areas of active investigation, driving the need for reliable HUNK antibodies to advance both basic and translational research.