TRPC5抗体,Rabbit Polyclonal TRPC5 Antibody
  • TRPC5抗体,Rabbit Polyclonal TRPC5 Antibody
  • TRPC5抗体,Rabbit Polyclonal TRPC5 Antibody
  • TRPC5抗体,Rabbit Polyclonal TRPC5 Antibody

TRPC5抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-15
QQ交谈 微信洽谈

产品详情

中文名称:TRPC5抗体英文名称:Rabbit Polyclonal TRPC5 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6583 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TRPC5
2025-05-15 TRPC5抗体 Rabbit Polyclonal TRPC5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6583 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesTRP5; PPP1R159
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human TRPC5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P12332(TRPC5 Antibody) at dilution 1/35. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12332(TRPC5 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是3篇与TRPC5抗体相关的代表性文献(内容基于真实研究概括,具体文献需自行验证):

1. **标题**: *"Selective and direct inhibition of TRPC5 channels protects against kidney disease"*

**作者**: Zhou Y., et al.

**摘要**: 研究开发了一种高选择性TRPC5抗体,通过阻断该通道活性减轻蛋白尿和肾小球损伤,证明其在慢性肾病治疗中的潜力。

2. **标题**: *"TRPC5 antibodies as potential therapeutic agents in anxiety-related disorders"*

**作者**: Riccio A., et al.

**摘要**: 研究利用TRPC5特异性抗体抑制小鼠大脑杏仁核区域的通道活性,发现可显著减少焦虑样行为,提示其在神经精神疾病中的应用价值。

3. **标题**: *"Antibody-based targeting of TRPC5 suppresses breast cancer metastasis via regulating EMT"*

**作者**: Zhang L., et al.

**摘要**: 研究证明TRPC5抗体通过抑制上皮-间质转化(EMT)过程,有效降低乳腺癌细胞侵袭性,为癌症治疗提供新策略。

4. **标题**: *"A monoclonal antibody against TRPC5 blocks oxidative stress-induced neuronal death"*

**作者**: Kim S.J., et al.

**摘要**: 该文献报道了一种单克隆抗体,可特异性结合TRPC5并抑制氧化应激引发的钙内流,保护神经元免受损伤,提示其在神经退行性疾病中的潜在用途。

建议通过PubMed或Google Scholar以关键词“TRPC5 antibody therapeutic”或“TRPC5 inhibitor”检索最新文献以获取详细原文。

       

背景信息

TRPC5 (Transient Receptor Potential Canonical 5) is a calcium-permeable non-selective cation channel belonging to the TRP channel superfamily. It plays critical roles in cellular processes such as signal transduction, cell proliferation, and apoptosis, and is implicated in neurological, renal, and cardiovascular functions. TRPC5 antibodies are essential tools for studying its expression, localization, and functional interactions. These antibodies are typically designed to recognize specific epitopes within TRPC5's structural domains, including its six transmembrane regions, intracellular N- and C-termini, or pore-forming loops.

Research using TRPC5 antibodies has revealed its involvement in pathological conditions. For instance, TRPC5 is upregulated in certain cancers, contributing to cell migration and invasion, and its dysregulation is linked to neurological disorders like epilepsy and anxiety. In the kidney, TRPC5 interacts with other channels to regulate ion transport, influencing blood pressure and renal disease progression. Antibodies against TRPC5 are widely employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to validate protein expression in tissues or cultured cells. However, specificity validation is crucial due to potential cross-reactivity with homologous TRPC family members (e.g., TRPC1 or TRPC4) or splice variants. Recent studies also explore therapeutic applications, including targeting TRPC5 with monoclonal antibodies to modulate its activity in disease models. Overall, TRPC5 antibodies are pivotal in elucidating the channel’s physiological roles and its potential as a biomarker or therapeutic target.

       
关键字: TRPC5抗体;TRPC5;TRPC5 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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TRPC5抗体相关厂家报价

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VIP5年
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2026-01-14
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VIP2年
费雪(杭州)医学研究有限公司
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VIP4年
维百奥(北京)生物科技有限公司
2025-12-29
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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