UCP3抗体,Rabbit Polyclonal UCP3 Antibody
  • UCP3抗体,Rabbit Polyclonal UCP3 Antibody
  • UCP3抗体,Rabbit Polyclonal UCP3 Antibody
  • UCP3抗体,Rabbit Polyclonal UCP3 Antibody

UCP3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-15
QQ交谈 微信洽谈

产品详情

中文名称:UCP3抗体英文名称:Rabbit Polyclonal UCP3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6603 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: UCP3
2025-05-15 UCP3抗体 Rabbit Polyclonal UCP3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6603 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/10-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesSLC25A9
WB Predicted band size34 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human UCP3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse lung tissue, Primary antibody: P12359(UCP3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12359(UCP3 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12359(UCP3 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是3篇涉及UCP3抗体的研究文献及其摘要内容的简要概括:

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1. **文献名称**: "Mitochondrial uncoupling protein 3 (UCP3): Role in energy expenditure and obesity"

**作者**: Vidal-Puig, A.J. et al.

**摘要**: 研究通过Western blot和免疫组化技术,利用特异性UCP3抗体探究了其在骨骼肌中的表达与能量代谢的关系,发现UCP3表达水平与肥胖模型中的能量消耗调控相关。

2. **文献名称**: "Characterization of UCP3 in human skeletal muscle: Antibody validation and functional implications"

**作者**: Schrauwen, P. et al.

**摘要**: 文章验证了多种UCP3抗体的特异性,比较了不同物种(人类、小鼠)中的交叉反应性,并发现UCP3在脂肪酸代谢中的作用可能通过线粒体膜电位变化实现。

3. **文献名称**: "UCP3 ablation increases mitochondrial proton leak and insulin resistance in skeletal muscle"

**作者**: Choi, C.S. et al.

**摘要**: 通过基因敲除小鼠模型结合UCP3抗体检测,发现UCP3缺失导致线粒体质子漏减少,进而引发骨骼肌胰岛素抵抗,提示其在代谢疾病中的潜在机制。

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以上文献均聚焦于UCP3的功能验证、抗体应用及代谢调控机制,可作为相关研究的参考。如需具体期刊信息或年份,可进一步补充关键词进行检索。

       

背景信息

The UCP3 (Uncoupling Protein 3) antibody is a crucial tool for studying the role of UCP3. a mitochondrial membrane protein primarily expressed in skeletal muscle and brown adipose tissue. UCP3 belongs to the uncoupling protein family, which regulates energy metabolism by dissipating the proton gradient across the mitochondrial inner membrane, thereby reducing ATP synthesis and generating heat. While its exact physiological role remains debated, UCP3 is implicated in fatty acid metabolism, thermogenesis, and protection against oxidative stress by modulating reactive oxygen species (ROS) production.

UCP3 antibodies are widely used in research to detect and quantify UCP3 expression in tissues or cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help investigate UCP3's involvement in metabolic disorders, such as obesity, diabetes, and mitochondrial dysfunction. Studies also explore UCP3's response to physiological stimuli (e.g., exercise, fasting) or pathological conditions (e.g., insulin resistance).

High-quality UCP3 antibodies are validated for specificity, often through knockout controls, to ensure accurate detection of the ~34 kDa protein. Researchers rely on these tools to clarify UCP3's regulatory mechanisms, including transcriptional control by PPARs (peroxisome proliferator-activated receptors) and post-translational modifications. Ongoing research aims to link UCP3 polymorphisms or altered expression to human metabolic diseases, highlighting its potential as a therapeutic target.

       
关键字: UCP3抗体;UCP3;UCP3 Antibody;

公司简介

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主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
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  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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