VSIG10抗体,Rabbit Polyclonal VSIG10 Antibody
  • VSIG10抗体,Rabbit Polyclonal VSIG10 Antibody
  • VSIG10抗体,Rabbit Polyclonal VSIG10 Antibody
  • VSIG10抗体,Rabbit Polyclonal VSIG10 Antibody

VSIG10抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-15
QQ交谈 微信洽谈

产品详情

中文名称:VSIG10抗体英文名称:Rabbit Polyclonal VSIG10 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6619 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: VSIG10
2025-05-15 VSIG10抗体 Rabbit Polyclonal VSIG10 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6619 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human VSIG10
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12385(VSIG10 Antibody) at dilution 1/35. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12385(VSIG10 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是关于VSIG10抗体的部分文献示例(注:因实际研究可能有限,以下信息为模拟示例,供参考):

1. **"VSIG10 as a Novel Immune Checkpoint: Characterization of Its Antibody in Tumor Microenvironment Modulation"**

*Authors: Li X, Chen Y, et al. (2022)*

**摘要**:本研究开发了一种靶向VSIG10的单克隆抗体,证实其在体外可阻断VSIG10与配体的相互作用,并在小鼠模型中增强抗肿瘤免疫应答,提示其作为免疫治疗新靶点的潜力。

2. **"Development of a High-Affinity Anti-VSIG10 Antibody for Autoimmune Disease Intervention"**

*Authors: Park S, Kim H (2021)*

**摘要**:通过噬菌体展示技术筛选出人源化抗VSIG10抗体,实验显示其能有效抑制VSIG10介导的T细胞抑制信号,在类风湿性关节炎模型中缓解炎症反应。

3. **"VSIG10 Antibody-Based Detection of Protein Expression in Colorectal Cancer Prognosis"**

*Authors: Wang R, et al. (2020)*

**摘要**:利用特异性抗VSIG10抗体进行免疫组化分析,发现VSIG10在结直肠癌组织中高表达,且与患者生存率负相关,提示其作为预后标志物的可能性。

4. **"Structural Insights into VSIG10-Antibody Interaction by Cryo-EM"**

*Authors: Gupta A, et al. (2023)*

**摘要**:通过冷冻电镜解析了VSIG10与其治疗性抗体的复合物结构,揭示了抗体中和VSIG10免疫抑制功能的关键表位,为抗体药物优化提供结构基础。

**说明**:若需真实文献,建议通过PubMed或Google Scholar以“VSIG10 antibody”或“VSIG10 therapeutic targeting”为关键词检索,并筛选近年发表的实验性研究。

       

背景信息

VSIG10 (V-set and immunoglobulin domain-containing protein 10), also known as CTHRC3 (collagen triple helix repeat-containing protein 3), is a transmembrane protein belonging to the immunoglobulin superfamily. Structurally, it contains an extracellular V-set Ig-like domain and a collagen triple helix repeat, suggesting roles in cell adhesion and extracellular matrix interactions. VSIG10 is expressed in various tissues, including the brain, retina, and reproductive organs, with emerging evidence implicating it in neurodevelopment, retinal function, and immune regulation.

Antibodies targeting VSIG10 are primarily used as research tools to investigate its expression patterns, molecular interactions, and biological functions. In disease contexts, VSIG10 has been linked to cancer progression, particularly in gliomas and colorectal cancers, where its overexpression correlates with tumor invasiveness and poor prognosis. Additionally, studies suggest its involvement in immune modulation, potentially influencing T-cell activity and inflammatory responses.

VSIG10 antibodies enable detection via techniques like immunohistochemistry, Western blotting, and flow cytometry, aiding in mechanistic studies and biomarker validation. Recent research also explores its therapeutic potential, with antibody-based strategies targeting VSIG10 in preclinical models to disrupt oncogenic signaling or modulate immune checkpoints. Despite these advances, the full scope of VSIG10's physiological and pathological roles remains under investigation, highlighting the continued importance of specific antibodies in elucidating its multifaceted biology.

       
关键字: VSIG10抗体;VSIG10;VSIG10 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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