ZFAND2A (zinc finger AN1-type containing 2A), also known as AIRAP or AN1D, is a ubiquitously expressed protein characterized by its AN1-type zinc finger domain, which is implicated in protein-protein interactions and ubiquitin-dependent processes. This protein plays a role in cellular stress responses, particularly under conditions like endoplasmic reticulum (ER) stress or proteasome inhibition. Studies suggest ZFAND2A acts as a regulatory factor in the ubiquitin-proteasome system, potentially modulating protein degradation by interacting with proteasome subunits or stress-responsive chaperones. It has also been linked to insulin sensitivity and metabolic regulation, with altered expression observed in diabetes and obesity models.
ZFAND2A antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation to investigate ZFAND2A's role in cellular stress pathways, protein homeostasis, and disease mechanisms. Validated antibodies typically target specific epitopes within the N-terminal or zinc finger domains, with specificity confirmed via knockout controls. Research applications include exploring its involvement in cancer progression, neurodegenerative diseases, and metabolic disorders, where dysregulation of proteostasis or stress signaling may contribute to pathogenesis. Reliable ZFAND2A antibodies are critical for advancing insights into its dual roles as a stress adaptor and potential therapeutic target.