CD122抗体,Mouse Monoclonal CD122 Antibody
  • CD122抗体,Mouse Monoclonal CD122 Antibody
  • CD122抗体,Mouse Monoclonal CD122 Antibody
  • CD122抗体,Mouse Monoclonal CD122 Antibody

CD122抗体—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-15
QQ交谈 微信洽谈

产品详情

中文名称:CD122抗体英文名称:Mouse Monoclonal CD122 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1048 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CD122
2025-05-15 CD122抗体 Mouse Monoclonal CD122 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1048 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesIL2RB; IL15RB; P70-75
Entrez GeneID3560
clone1G11C6
WB Predicted band size61kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD122 (AA: extra 27-240) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of HL-60 cells using CD122 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of Jurkat cells using CD122 mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于CD122抗体的3篇示例文献(注:内容为模拟虚构,仅供参考):

1. **文献名称**:*Targeting CD122 enhances NK cell activation and antitumor immunity*

**作者**:Zhang et al., 2021

**摘要**:研究开发了一种人源化抗CD122激动型抗体,通过增强IL-2信号通路,显著提升自然杀伤(NK)细胞活性,并在小鼠模型中抑制黑色素瘤生长,为癌症免疫治疗提供新策略。

2. **文献名称**:*CD122 blockade inhibits autoreactive T cells in experimental autoimmune encephalomyelitis*

**作者**:Kumar et al., 2019

**摘要**:通过抗CD122抗体阻断IL-2受体β亚基,抑制自身反应性T细胞的增殖和分化,有效缓解多发性硬化症模型小鼠的神经炎症,提示其在自身免疫疾病治疗中的潜力。

3. **文献名称**:*Engineered anti-CD122 antibody-drug conjugate for targeted T-cell lymphoma therapy*

**作者**:Chen et al., 2022

**摘要**:该研究构建了靶向CD122的抗体-药物偶联物(ADC),在体外和体内实验中选择性杀伤T细胞淋巴瘤细胞,同时减少对正常免疫细胞的影响,为血液肿瘤治疗提供新方向。

4. **文献名称**:*CD122-directed bispecific antibody enhances viral-specific T cell responses in chronic infection*

**作者**:Wang et al., 2020

**摘要**:设计了一种靶向CD122和病毒抗原的双特异性抗体,通过增强IL-2信号与抗原呈递协同作用,恢复慢性病毒感染模型中的T细胞功能,为抗病毒免疫治疗提供新思路。

(注:上述文献为示例,非真实存在。实际研究中建议通过PubMed等数据库检索具体文献。)

       

背景信息

CD122. also known as interleukin-2 receptor beta (IL-2Rβ), is a subunit of the IL-2 receptor complex expressed on immune cells, including T cells, B cells, and natural killer (NK) cells. It pairs with the common gamma chain (γc, CD132) to form a functional receptor for IL-2 and IL-15. cytokines critical for lymphocyte activation, proliferation, and homeostasis. CD122 is particularly important in regulating effector and memory T cell responses, as well as NK cell function.

CD122-targeting antibodies are designed to modulate immune activity by either blocking or activating this receptor pathway. In therapeutic contexts, antagonistic anti-CD122 antibodies have been explored to suppress excessive immune activation in autoimmune diseases or organ transplantation by interfering with IL-2/IL-15 signaling. Conversely, agonistic antibodies may enhance antitumor immunity by promoting T cell or NK cell activity, potentially synergizing with checkpoint inhibitors.

Research applications of CD122 antibodies include flow cytometry for immune cell profiling, functional studies of IL-2/IL-15 pathways, and preclinical models of cancer or autoimmunity. Challenges in targeting CD122 involve balancing its dual roles in pro-inflammatory and regulatory immune subsets (e.g., effector T cells vs. Tregs). Recent studies also investigate its combination with cytokine therapies to optimize specificity and reduce systemic toxicity.

       
关键字: CD122抗体;CD122;CD122 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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