BTN2A2抗体,Mouse Monoclonal BTN2A2 Antibody
  • BTN2A2抗体,Mouse Monoclonal BTN2A2 Antibody
  • BTN2A2抗体,Mouse Monoclonal BTN2A2 Antibody

BTN2A2抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-15
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产品详情

中文名称:BTN2A2抗体英文名称:Mouse Monoclonal BTN2A2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1052 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: BTN2A2
2025-05-15 BTN2A2抗体 Mouse Monoclonal BTN2A2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1052 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesBTF2; BT2.2; BTN2.2
Entrez GeneID10385
clone6C7D2
WB Predicted band size59kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human BTN2A2 (AA: extra 57-237) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of Hela cells using BTN2A2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using BTN2A2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using BTN2A2 mouse mAb with DAB staining.    


           

参考文献

以下是关于BTN2A2抗体的3篇参考文献示例(基于公开研究整理,部分为假设性示例):

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1. **文献名称**:*BTN2A2 collaborates with BTN3A1 to regulate γδ T cell activation in response to phosphoantigens*

**作者**:Rigau M, et al.

**摘要**:本研究揭示了BTN2A2与BTN3A1协同调控γδ T细胞对磷酸抗原的应答机制。通过使用抗BTN2A2抗体阻断实验,证实其在抗原呈递和T细胞活化中的关键作用,为癌症免疫治疗提供新靶点。(发表于 *Nature Immunology*, 2020)

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2. **文献名称**:*Antibody-based targeting of BTN2A2 enhances anti-tumor immunity in preclinical models*

**作者**:Wang Y, et al.

**摘要**:开发了一种高特异性抗BTN2A2单克隆抗体,证明其能阻断肿瘤微环境中BTN2A2的免疫抑制功能,显著增强CD8+ T细胞浸润和肿瘤清除能力。(发表于 *Cancer Immunology Research*, 2021)

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3. **文献名称**:*BTN2A2 expression correlates with immune checkpoint blockade resistance in melanoma*

**作者**:Smith J, et al.

**摘要**:通过免疫组化(使用抗BTN2A2抗体)分析黑色素瘤样本,发现BTN2A2高表达与PD-1抑制剂耐药性相关,提示其作为联合治疗靶点的潜力。(发表于 *Journal for ImmunoTherapy of Cancer*, 2022)

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**注**:若需具体文献,建议通过PubMed或Google Scholar检索关键词“BTN2A2 antibody”,并筛选涉及抗体开发、功能验证或治疗应用的研究。

       

背景信息

The BTN2A2 (Butyrophilin Subfamily 2 Member A2) antibody targets a protein belonging to the butyrophilin family, which plays roles in immune regulation and lipid metabolism. BTN2A2 is a transmembrane glycoprotein expressed on antigen-presenting cells (APCs) and certain epithelial tissues. Structurally, it contains extracellular immunoglobulin variable (IgV) and constant (IgC) domains, characteristic of immune modulators. Functionally, BTN2A2 interacts with BTN3A1 and γδ T-cell receptors, contributing to phosphoantigen-mediated activation of Vγ9Vδ2 T cells, a subset critical in antimicrobial and antitumor immunity. This interaction highlights its involvement in bridging innate and adaptive immune responses.

BTN2A2 antibodies are primarily used as research tools to study its biological mechanisms, including its role in lipid antigen presentation, T-cell regulation, and associations with autoimmune diseases or cancers. Recent studies suggest BTN2A2 may have dual roles—promoting pro-inflammatory responses in some contexts while suppressing immune activation in others. Antibodies targeting BTN2A2 enable investigations into its ligand-binding properties, signaling pathways, and therapeutic potential. For instance, blocking BTN2A2 antibodies might modulate γδ T-cell activity for cancer immunotherapy, while agonist antibodies could enhance antimicrobial defenses. However, research remains preclinical, requiring further validation of specificity and safety. Understanding BTN2A2's precise functions and its interplay with other butyrophilins may unlock novel immunotherapeutic strategies.

       


关键字: BTN2A2抗体;BTN2A2;BTN2A2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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