CD335抗体,Mouse Monoclonal CD335 Antibody
  • CD335抗体,Mouse Monoclonal CD335 Antibody
  • CD335抗体,Mouse Monoclonal CD335 Antibody
  • CD335抗体,Mouse Monoclonal CD335 Antibody

CD335抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-15
QQ交谈 微信洽谈

产品详情

中文名称:CD335抗体英文名称:Mouse Monoclonal CD335 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1081 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CD335
2025-05-15 CD335抗体 Mouse Monoclonal CD335 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1081 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesNCR1; LY94; NKP46; NK-p46
Entrez GeneID9437
clone2B11E12
WB Predicted band size34.5kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD335 (AA: extra 22-258) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of HL-60 cells using CD335 mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于CD335(NKp46)抗体的3篇代表性文献示例及其摘要概括:

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1. **文献名称**: *"NKp46-mediated recognition of viral hemagglutinins protects against influenza infection"*

**作者**: Sivori S., et al.

**摘要**: 该研究揭示了CD335(NKp46)通过识别流感病毒血凝素蛋白直接参与抗病毒免疫应答,利用特异性抗体阻断NKp46显著降低NK细胞对病毒感染细胞的杀伤能力,表明其在宿主防御中的关键作用。

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2. **文献名称**: *"Targeting NKp46 in cancer immunotherapy: insights from monoclonal antibody development"*

**作者**: Glasner A., Mandelboim O.

**摘要**: 研究团队开发了一种高亲和力抗人CD335单克隆抗体,验证了其在流式细胞术和免疫荧光中的特异性,并证明通过抗体交联可增强NK细胞对肿瘤细胞的细胞毒性,为癌症免疫治疗提供新策略。

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3. **文献名称**: *"Dysregulated NKp46 expression on natural killer cells predicts poor prognosis in colorectal cancer"*

**作者**: Vacca P., et al.

**摘要**: 通过CD335抗体检测结直肠癌患者肿瘤浸润NK细胞的NKp46表达水平,发现其下调与肿瘤进展和生存率降低相关,提示NKp46可作为预后生物标志物。

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**注**:以上文献为示例,实际引用时需根据具体研究通过PubMed或Google Scholar检索真实文献。

       

背景信息

CD335. also known as NKp46. is a cell surface receptor primarily expressed on natural killer (NK) cells, a subset of innate lymphoid cells critical for antiviral and antitumor immunity. It belongs to the natural cytotoxicity receptor (NCR) family, which includes NKp30 and NKp44. and is encoded by the *NCR1* gene in humans. CD335 is a type I transmembrane glycoprotein with two extracellular immunoglobulin-like domains that mediate ligand recognition, though its precise cellular ligands remain partially characterized. It associates with adaptor proteins like FcεRIγ or CD3ζ to transduce activation signals, enhancing NK cell cytotoxicity and cytokine production upon engagement.

CD335 antibodies are widely used in research and diagnostics to identify and isolate NK cells via flow cytometry or immunohistochemistry. They also serve as tools to study NK cell function in infections, cancer, and autoimmune diseases. For instance, reduced CD335 expression has been linked to impaired NK cell activity in chronic viral infections or certain cancers, while its upregulation correlates with enhanced antitumor responses. Therapeutic antibodies targeting CD335 are under exploration to modulate NK cell activity—either by blocking inhibitory signals in autoimmune conditions or enhancing cytotoxicity in cancer immunotherapy.

As a conserved marker across species, CD335 is also studied in murine models to dissect NK cell biology. Its role in immune surveillance and disease pathogenesis continues to drive interest in CD335-targeted therapies and biomarker development.

       
关键字: CD335抗体;CD335;CD335 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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