The NAGR1 (Nogo-A Activated Glucocorticoid Receptor 1) antibody is a tool used to study the NAGR1 protein, a regulator linked to glucocorticoid signaling and neural plasticity. NAGR1 is activated by Nogo-A, a myelin-associated protein known to inhibit axonal regeneration in the central nervous system (CNS). This interaction suggests NAGR1 may mediate Nogo-A’s effects on neuronal growth and synaptic plasticity, particularly in contexts of CNS injury or neurodegenerative diseases.
NAGR1 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. They enable detection of NAGR1 expression via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), helping researchers map its distribution in neural tissues and other cell types. Studies utilizing these antibodies have explored NAGR1’s role in modulating glucocorticoid receptor activity, which influences stress responses, inflammation, and neuronal repair mechanisms.
Research applications extend to conditions like spinal cord injury, multiple sclerosis, and psychiatric disorders, where dysregulated Nogo-A/NAGR1 pathways may contribute to pathology. Additionally, NAGR1 antibodies aid in investigating crosstalk between neural regeneration inhibitors and hormonal signaling, offering insights into therapeutic strategies targeting CNS repair. Validated antibodies are critical for specificity, as cross-reactivity with related glucocorticoid receptor family members can confound results.