CD208 antibody targets the CD208 antigen, also known as dendritic cell-lysosomal associated membrane protein (DC-LAMP) or LAMP3. a transmembrane glycoprotein predominantly expressed in mature dendritic cells (DCs). CD208 is localized in the MHC class II loading compartments (MIICs) of DCs, where it plays a role in antigen processing and presentation. Its expression is closely associated with DC maturation, serving as a marker for activated, immunologically functional DCs.
CD208 antibodies are widely used in research to identify and study mature DC populations in tissues, immune responses, and pathological conditions such as cancer, autoimmune diseases, and infections. For example, elevated CD208+ DCs in tumor microenvironments correlate with T-cell activation and improved clinical outcomes, while reduced levels may indicate immune evasion. These antibodies also aid in distinguishing DC subsets in flow cytometry, immunohistochemistry, and immunofluorescence.
Structurally, CD208 belongs to the LAMP family, featuring a luminal domain with conserved glycosylation sites and a short cytoplasmic tail. Its gene, LAMP3. is regulated by cytokines like TNF-α and IFN-γ, linking its expression to inflammatory signaling. CD208 antibodies thus provide critical insights into DC biology, immune regulation, and therapeutic strategies targeting antigen-presenting cells. Their applications extend to vaccine development, immunotherapy monitoring, and biomarker discovery in immunological disorders.