CD11D抗体,Mouse Monoclonal CD11D Antibody
  • CD11D抗体,Mouse Monoclonal CD11D Antibody
  • CD11D抗体,Mouse Monoclonal CD11D Antibody
  • CD11D抗体,Mouse Monoclonal CD11D Antibody

CD11D抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-15
QQ交谈 微信洽谈

产品详情

中文名称:CD11D抗体英文名称:Mouse Monoclonal CD11D Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1169 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CD11D
2025-05-15 CD11D抗体 Mouse Monoclonal CD11D Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1169 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesITGAD; ADB2
Entrez GeneID3681
clone3D7A6
WB Predicted band size126.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD11D (AA: extra 18-172) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of HL-60 cells using CD11D mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于CD11D抗体的3篇参考文献示例(注:文献标题和作者为模拟示例,实际需根据真实文献调整):

1. **标题**:*Targeting CD11d attenuates leukocyte recruitment and improves outcomes in a murine model of ischemic stroke*

**作者**:Grayson MH, et al.

**摘要**:研究证明,使用CD11D抗体阻断整合素CD11d/CD18可减少缺血性中风模型中的白细胞浸润,降低脑损伤面积并改善神经功能恢复。

2. **标题**:*CD11d/CD18 integrin blockade reduces macrophage infiltration and atherosclerosis in ApoE-deficient mice*

**作者**:Wu L, et al.

**摘要**:通过CD11D抗体抑制CD11d/CD18活性,显著减少动脉粥样硬化模型小鼠的巨噬细胞浸润和斑块形成,提示其潜在抗动脉粥样硬化作用。

3. **标题**:*Anti-CD11d therapy mitigates neuroinflammation and spinal cord injury through modulation of neutrophil migration*

**作者**:Saville LR, et al.

**摘要**:在脊髓损伤模型中,CD11D抗体通过抑制中性粒细胞迁移和促炎因子释放,有效减轻神经炎症并促进组织修复。

建议通过PubMed或Google Scholar搜索真实文献,使用关键词“CD11D antibody”或“anti-CD11d integrin”获取具体研究。

       

背景信息

CD11D antibody targets the CD11d integrin subunit, a member of the β2-integrin family. CD11d pairs noncovalently with CD18 to form the αDβ2 integrin (CD11d/CD18), primarily expressed on subsets of leukocytes, including monocytes, macrophages, and activated lymphocytes. Unlike other β2-integrins (e.g., CD11a, CD11b), CD11d exhibits distinct ligand-binding properties, interacting with vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-3 (ICAM-3), and extracellular matrix components. This integrin mediates leukocyte adhesion, migration, and activation in inflammatory and immune responses, particularly in chronic or non-resolving inflammatory conditions.

CD11d is implicated in pathologies such as atherosclerosis, multiple sclerosis, and ischemic stroke, where its overexpression enhances leukocyte infiltration into tissues. Research using CD11d antibodies has highlighted its role in modulating immune cell trafficking and inflammation in preclinical models. For instance, blocking CD11d/CD18 with specific antibodies reduces neuroinflammation and tissue damage in experimental autoimmune encephalomyelitis (EAE) and stroke models. These antibodies are valuable tools for studying integrin-mediated signaling pathways and validating therapeutic targets. Despite its lower profile compared to other β2-integrins, CD11d's unique expression patterns and ligand interactions make it a focus for developing targeted therapies against inflammatory diseases. Current challenges include optimizing antibody specificity and understanding context-dependent roles in different disease microenvironments.

       
关键字: CD11D抗体;CD11D;CD11D Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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