The DYRK4 (Dual Specificity Tyrosine Phosphorylation-Regulated Kinase 4) antibody is a tool used to study the function and expression of the DYRK4 protein, a member of the CMGC kinase group. DYRK4 belongs to the DYRK family, which regulates diverse cellular processes, including cell cycle progression, differentiation, and survival. Unlike its well-characterized relatives DYRK1A or DYRK2. DYRK4 remains less studied, though it shares conserved kinase domains and autophosphorylation activity. It is expressed in tissues like the testis, brain, kidney, and heart, suggesting roles in development and tissue homeostasis.
DYRK4-specific antibodies are essential for detecting protein localization, expression levels, and interactions in experimental models. They enable techniques such as Western blotting, immunoprecipitation, and immunohistochemistry. Research using these antibodies has linked DYRK4 to pathways involving Wnt signaling, RNA processing, and stress responses. Emerging studies implicate DYRK4 dysregulation in diseases; for example, its overexpression has been observed in certain cancers, potentially influencing tumor progression. Additionally, DYRK4 may interact with proteins associated with neurodegenerative conditions, though mechanistic insights are limited.
The development of high-specificity, validated DYRK4 antibodies is critical for clarifying its biological roles and therapeutic potential. Current challenges include minimizing cross-reactivity with other DYRK family members and standardizing detection across experimental platforms. Ongoing research aims to explore DYRK4's involvement in developmental disorders, cancer, and neurological diseases, positioning it as a target for future drug discovery.