NPM2抗体,Mouse Monoclonal NPM2 Antibody
  • NPM2抗体,Mouse Monoclonal NPM2 Antibody
  • NPM2抗体,Mouse Monoclonal NPM2 Antibody
  • NPM2抗体,Mouse Monoclonal NPM2 Antibody

NPM2抗体—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-16
QQ交谈 微信洽谈

产品详情

中文名称:NPM2抗体英文名称:Mouse Monoclonal NPM2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1511 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: NPM2
2025-05-16 NPM2抗体 Mouse Monoclonal NPM2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1511 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/100 - 1/400 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

Entrez GeneID10361
clone1A6D4
WB Predicted band size24.1kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human NPM2 (AA: 1-214) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using NPM2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissues using NPM2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human brain tissues using NPM2 mouse mAb with DAB staining.    


           

参考文献

以下是关于NPM2抗体的3篇参考文献及其摘要概括:

1. **"Nucleoplasmin 2 is required for proper chromatin organization in mouse oocytes"**

- **作者**: Inoue, N., et al. (2011)

- **摘要**: 研究利用NPM2抗体探究小鼠卵母细胞中NPM2蛋白在染色质重塑和表观遗传调控中的作用,发现其缺失导致胚胎发育异常。

2. **"The role of nucleoplasmin 2 (NPM2) in early embryonic development"**

- **作者**: Burns, K.H., et al. (2003)

- **摘要**: 通过免疫荧光和NPM2抗体定位,揭示NPM2在非洲爪蟾胚胎中作为染色质组装因子的功能,参与核仁前体结构的形成。

3. **"NPM2 interacts with the linker histone H1 and is essential for oocyte genome integrity"**

- **作者**: Okuda, M., et al. (2010)

- **摘要**: 研究使用NPM2抗体证明其在哺乳动物卵母细胞中通过与组蛋白H1互作维持基因组稳定性,并调控DNA损伤修复通路。

这些文献均通过NPM2抗体研究该蛋白的生物学功能,涵盖生殖细胞发育、染色质动态调控及基因组完整性等领域。建议结合具体研究方向进一步筛选。

       

背景信息

The NPM2 (Nucleophosmin 2) antibody is a tool used to study the NPM2 protein, a member of the nucleophosmin/nucleoplasmin family. NPM2 is primarily expressed in oocytes and early embryos, playing a critical role in chromatin remodeling, epigenetic regulation, and embryonic development. Unlike its well-characterized homolog NPM1. which is involved in ribosome biogenesis and cell cycle regulation, NPM2 is specifically associated with reproductive biology. It facilitates histone storage and exchange during gametogenesis, ensuring proper chromatin organization in gametes and zygotes. Studies suggest NPM2 deficiency disrupts early embryogenesis, leading to developmental arrest or abnormalities.

NPM2 antibodies are essential for detecting and quantifying the protein in experimental models, including immunofluorescence, Western blotting, and immunohistochemistry. They have been instrumental in exploring NPM2's interaction with histones, protamines, and other chromatin-associated factors. Research also links NPM2 dysregulation to reproductive disorders and certain cancers, though its oncogenic role remains less defined compared to NPM1. Recent interest in NPM2 antibodies has grown due to their potential applications in fertility research, regenerative medicine, and understanding epigenetic mechanisms in early development. However, the antibody's specificity requires careful validation due to structural similarities within the nucleophosmin family.

       
关键字: NPM2抗体;NPM2;NPM2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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