The WHSC2 (Wolf-Hirschhorn syndrome candidate 2) antibody is a tool used to detect the WHSC2 protein, encoded by the *WHSC2* gene located on chromosome 4p16.3. This gene lies within the critical region associated with Wolf-Hirschhorn syndrome (WHS), a rare genetic disorder characterized by developmental delays, craniofacial abnormalities, and intellectual disabilities. While WHSC2’s exact function remains under investigation, studies suggest it may play roles in transcriptional regulation, RNA processing, or chromatin remodeling. It shares genomic proximity with *WHSC1* (NSD2), a histone methyltransferase implicated in cancers like multiple myeloma, but WHSC2 itself is not directly linked to oncogenic pathways.
Antibodies targeting WHSC2 are primarily utilized in research to explore its expression patterns, subcellular localization, and interactions in cellular models. They are employed in techniques such as Western blotting, immunofluorescence, and immunohistochemistry. Despite limited clinical applications, these antibodies aid in elucidating WHSC2’s potential contributions to developmental processes and its relevance to WHS pathology. Current studies also investigate whether WHSC2 interacts with other WHS-associated genes (e.g., *LETM1*, *FGFR3*) to modulate phenotypic outcomes. However, challenges persist in defining its precise molecular mechanisms, highlighting the need for further functional studies. The WHSC2 antibody thus serves as a critical reagent for dissecting the biological and pathological roles of this understudied protein.