ZKSCAN3抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P02251(ZKSCAN3 Antibody) at dilution 1/125. (Original magnification: ×200)    

  
  

ZKSCAN3 (Zinc Finger with KRAB and SCAN Domains 3) is a transcription factor belonging to the zinc finger protein family, characterized by its KRAB (Krüppel-associated box) and SCAN domains. It is implicated in regulating gene expression by binding to specific DNA sequences, particularly in regions rich in GC nucleotides. ZKSCAN3 has been studied primarily for its role in modulating cellular processes such as proliferation, autophagy, and tumorigenesis. Research suggests it acts as a transcriptional repressor, suppressing genes involved in autophagy and lysosomal biogenesis, thereby influencing cellular homeostasis under stress conditions.

Antibodies targeting ZKSCAN3 are essential tools for investigating its expression, localization, and function. They are widely used in techniques like Western blotting, chromatin immunoprecipitation (ChIP), and immunofluorescence (IF) to study ZKSCAN3's interaction partners, DNA-binding activity, and subcellular distribution. Studies using these antibodies have revealed ZKSCAN3's dual role in cancer—acting as both a potential tumor suppressor and an oncogenic driver, depending on context. For instance, ZKSCAN3 downregulation correlates with enhanced autophagy and inhibited tumor growth in some cancers, while its overexpression promotes metastasis in others. Validated ZKSCAN3 antibodies are critical for resolving these context-dependent mechanisms, though challenges remain in ensuring specificity due to homology with other SCAN-ZNF proteins. Recent work also explores ZKSCAN3's involvement in metabolic regulation and immune response, highlighting its broader biological significance.