ZNF346 antibody is a research tool designed to detect and study the zinc finger protein 346 (ZNF346), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. ZNF346. also known as JAZ or ZSCAN42. is encoded by the *ZNF346* gene in humans and is implicated in transcriptional regulation and RNA metabolism. Structurally, it contains multiple C2H2-type zinc finger motifs, which enable sequence-specific DNA or RNA binding, and a KRAB domain that often mediates interactions with co-repressors to regulate gene silencing.
Studies suggest ZNF346 plays roles in cellular stress responses, apoptosis, and cancer progression. For example, it has been linked to modulating p53-dependent apoptotic pathways under oxidative stress and may act as a tumor suppressor in certain cancers. Dysregulation of ZNF346 expression has been observed in malignancies like hepatocellular carcinoma and glioblastoma.
The ZNF346 antibody is typically generated using recombinant protein fragments or synthetic peptides corresponding to specific epitopes of the human ZNF346 protein. It is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate ZNF346's expression patterns, subcellular localization (primarily nuclear), and interactions with other biomolecules. Validated antibodies are essential for exploring ZNF346's functional mechanisms, its involvement in disease pathways, and potential therapeutic applications. Researchers rely on these antibodies to dissect its role in gene regulation, RNA processing, and cellular homeostasis across normal and pathological conditions.