CHCHD5抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P02508(CHCHD5 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P02508(CHCHD5 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The CHCHD5 antibody is a critical tool for studying the CHCHD5 protein, a mitochondrial protein belonging to the coiled-coil-helix-coiled-coil-helix (CHCHD) domain-containing family. CHCHD5 is implicated in mitochondrial dynamics, apoptosis regulation, and cellular responses to oxidative stress. It localizes to the mitochondrial intermembrane space and interacts with components of the mitochondrial contact site and cristae organizing system (MICOS), influencing cristae structure and respiratory chain function. Dysregulation of CHCHD5 has been linked to neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s diseases) and cancers, where altered expression correlates with tumor progression or metastasis.

CHCHD5 antibodies, typically developed in hosts like rabbits or mice, enable the detection and quantification of endogenous CHCHD5 through techniques such as Western blotting, immunofluorescence, and immunohistochemistry. These antibodies aid in exploring CHCHD5’s role in mitochondrial homeostasis, its interaction partners, and its involvement in disease pathways. Validated antibodies are essential for specificity, as cross-reactivity with other CHCHD family members (e.g., CHCHD2. CHCHD10) can occur due to structural similarities.

Research using CHCHD5 antibodies has advanced understanding of mitochondrial dysfunction mechanisms, offering potential therapeutic targets. Their application in preclinical models and patient-derived samples underscores their translational relevance in diagnosing or treating mitochondrial disorders and cancers.