NCLN抗体,Rabbit Polyclonal NCLN Antibody
  • NCLN抗体,Rabbit Polyclonal NCLN Antibody
  • NCLN抗体,Rabbit Polyclonal NCLN Antibody
  • NCLN抗体,Rabbit Polyclonal NCLN Antibody

NCLN抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-16
QQ交谈 微信洽谈

产品详情

中文名称:NCLN抗体英文名称:Rabbit Polyclonal NCLN Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2332 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: NCLN
2025-05-16 NCLN抗体 Rabbit Polyclonal NCLN Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2332 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesDBP; GRD3; VDBG; VDBP; DBP/GC
WB Predicted band size53 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human GC
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Human fetal liver tissue, A549 cells, Primary antibody: P00791(GC Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P00791(GC Antibody) at dilution 1/40. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P00791(GC Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于NCLN(Nicalin)抗体的模拟参考文献示例(注:部分信息为假设性描述,实际文献需通过学术数据库核实):

---

1. **文献名称**: *Nicalin regulates embryonic dorsal-ventral patterning via TGF-β signaling*

**作者**: Haffner C, et al.

**摘要**: 研究揭示了NCLN蛋白通过调节TGF-β信号通路在斑马鱼胚胎背腹轴形成中的关键作用,利用特异性抗体进行免疫共沉淀实验,证实其与TGF-β受体复合物的相互作用。

2. **文献名称**: *Structural insights into Nicalin-mediated protein quality control in the endoplasmic reticulum*

**作者**: Wang L, et al.

**摘要**: 通过冷冻电镜解析NCLN蛋白复合体的三维结构,结合抗体标记技术阐明其在内质网相关降解(ERAD)中对错误折叠蛋白的识别机制。

3. **文献名称**: *Nicalin antibody-based profiling reveals dysregulation in neurodegenerative models*

**作者**: Tanaka K, et al.

**摘要**: 开发了一种高特异性NCLN单克隆抗体,用于阿尔茨海默病模型小鼠脑组织分析,发现NCLN表达水平与tau蛋白异常聚集呈负相关。

4. **文献名称**: *Nicalin modulates Notch signaling through interaction with Nicastrin*

**作者**: Denzel A, et al.

**摘要**: 利用NCLN抗体进行免疫荧光共定位实验,证明NCLN与Nicastrin形成复合物,调控Notch信号通路的活性,影响细胞分化进程。

---

建议通过PubMed或Google Scholar以关键词“Nicalin antibody”或“NCLN function”检索真实文献,并优先选择近5年高被引研究。

       

背景信息

The NCLN antibody is a research tool designed to target Nicalin (NCLN), a conserved transmembrane protein primarily localized in the endoplasmic reticulum (ER). Nicalin plays a critical role in ER-associated processes, including protein complex assembly, signal transduction, and cellular homeostasis. It forms a complex with Nodal modulator (NOMO) and interacts with proteins like TMEM147. influencing pathways such as the Notch signaling cascade, which is vital for embryonic development and cell differentiation. Dysregulation of NCLN has been linked to developmental disorders and cancer progression.

NCLN antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study Nicalin's expression, subcellular localization, and interactions. Researchers employ these antibodies to explore its role in modulating the Notch pathway by regulating the cleavage of ligands such as DLL1. as well as its potential involvement in stress responses and apoptosis. Additionally, NCLN antibodies aid in investigating pathological mechanisms in congenital anomalies or malignancies, where Nicalin's function may be disrupted. Their specificity and reliability make them essential for elucidating NCLN's molecular mechanisms in both physiological and disease contexts.

       
关键字: NCLN抗体;NCLN;NCLN Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

NCLN抗体—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
¥1800
VIP1年
费雪(杭州)医学研究有限公司
2025-07-14
询价
VIP3年
维百奥(北京)生物科技有限公司
2025-05-26
询价
上海华盈生物医药科技有限公司
2025-07-17
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.