The ZMAT4 (Zinc Finger Matrin-Type 4) antibody is a tool used to detect and study the ZMAT4 protein, a member of the zinc finger protein family characterized by matrin-type zinc finger domains. ZMAT4 is implicated in RNA metabolism, transcriptional regulation, and cellular stress responses. It contains multiple C2H2-type zinc finger motifs, which enable nucleic acid binding, suggesting roles in RNA splicing, stability, or translational control. While its exact biological functions remain under investigation, ZMAT4 has been linked to tumorigenesis, neurodevelopment, and apoptosis regulation. Studies suggest it may act as a tumor suppressor or oncogene depending on cellular context, with altered expression observed in cancers like glioblastoma and neuroblastoma.
ZMAT4 antibodies are essential for exploring its expression patterns, subcellular localization (primarily nuclear), and interactions with RNA or protein partners. These antibodies are validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence. Researchers rely on them to investigate ZMAT4's role in diseases, particularly its involvement in p53 signaling pathways and response to DNA damage. Commercial ZMAT4 antibodies are typically raised in hosts like rabbits or mice, with specificity confirmed via knockout controls.
Understanding ZMAT4's mechanisms could reveal therapeutic targets, especially in cancer and neurodegenerative disorders. Its dual roles in cell proliferation and apoptosis make it a compelling subject for studies on cellular homeostasis and disease progression.