GALNT12抗体—艾普蒂

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     Western blot analysis of SV40 Tantigen in A549, HL-60, U251 lysates using SV40 T Antigen antibody.    

  
  

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     Immunocytochemistry analysis of SV40 Tantigen (green) in hela using SV40 Tantigen antibody,and DAPI(blue)    

  
  

**Background of GALNT12 Antibody**

GALNT12 (polypeptide N-acetylgalactosaminyltransferase 12) is a member of the GALNT enzyme family responsible for initiating O-glycosylation, a post-translational modification critical for protein stability, trafficking, and cell-cell communication. Specifically, GALNT12 catalyzes the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine residues on target proteins, a key step in mucin-type O-glycosylation.

Research has linked GALNT12 to cancer biology, particularly colorectal cancer (CRC). Germline mutations in GALNT12 are associated with hereditary CRC susceptibility, suggesting its role as a tumor suppressor. Dysregulation of GALNT12 may impair glycosylation of substrates like MUC1 or EGFR, altering signaling pathways involved in cell proliferation and apoptosis.

Antibodies targeting GALNT12 are essential tools for studying its expression, localization, and function. They enable detection of GALNT12 in tissues or cell lines via techniques like immunohistochemistry, Western blotting, or immunofluorescence. Such studies help elucidate its tissue-specific roles, cancer-related mechanisms, and potential as a diagnostic or therapeutic biomarker. Commercial GALNT12 antibodies are typically validated for specificity against recombinant or endogenous proteins, though variability in isoforms or post-translational modifications may require careful experimental optimization. Ongoing research continues to explore GALNT12's broader implications in glycosylation disorders and malignancies.