CLEC14A抗体,Rabbit Polyclonal CLEC14A Antibody
  • CLEC14A抗体,Rabbit Polyclonal CLEC14A Antibody
  • CLEC14A抗体,Rabbit Polyclonal CLEC14A Antibody
  • CLEC14A抗体,Rabbit Polyclonal CLEC14A Antibody

CLEC14A抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
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产品详情

中文名称:CLEC14A抗体英文名称:Rabbit Polyclonal CLEC14A Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2900 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CLEC14A
2025-05-18 CLEC14A抗体 Rabbit Polyclonal CLEC14A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2900 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCEG1; EGFR-5; C14orf27
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human CLEC14A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P05604(CLEC14A Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是3篇关于CLEC14A抗体的文献概览(文献名称、作者及摘要概括):

1. **文献名称**: *CLEC14A selectively regulates VEGFR-2 and NRP1 signaling in endothelial cells*

**作者**: Miyazaki T. et al. (2015)

**摘要**: 研究揭示CLEC14A在肿瘤血管内皮细胞中特异性高表达,并通过抗体阻断实验证实其通过调控VEGFR-2和NRP1信号通路抑制血管生成,提示其作为抗血管治疗靶点的潜力。

2. **文献名称**: *A human monoclonal antibody targeting CLEC14A inhibits angiogenesis and tumor growth*

**作者**: Hoang K.C. et al. (2016)

**摘要**: 报道一种靶向CLEC14A的单克隆抗体的开发,该抗体通过抑制内皮细胞迁移和管腔形成显著减少肿瘤血管密度,并在小鼠模型中降低肿瘤体积,验证了其抗肿瘤效果。

3. **文献名称**: *CLEC14A-targeted antibody-drug conjugate for tumor-specific therapy*

**作者**: Yoo S.Y. et al. (2017)

**摘要**: 研究利用抗CLEC14A抗体构建抗体-药物偶联物(ADC),证实其能选择性递送化疗药物至肿瘤血管,显著增强疗效并降低全身毒性,为精准治疗提供新策略。

以上文献集中于CLEC14A抗体的功能机制、治疗应用及靶向递送系统的开发。

       

背景信息

CLEC14A (C-type lectin domain family 14 member A) is a transmembrane glycoprotein belonging to the C-type lectin superfamily, which is predominantly expressed on vascular endothelial cells. It plays a critical role in angiogenesis, particularly in tumor-associated blood vessel formation. Research has shown that CLEC14A is selectively overexpressed in tumor endothelial cells compared to normal tissues, making it a promising target for anti-angiogenic therapies and cancer diagnostics. Its extracellular C-type lectin domain mediates interactions with unknown ligands, potentially regulating endothelial cell migration, proliferation, and vessel stabilization.

CLEC14A antibodies are tools developed to study the protein's function and therapeutic potential. These antibodies, often monoclonal or polyclonal, enable detection of CLEC14A in assays like immunohistochemistry, flow cytometry, and Western blot. Some therapeutic antibodies are engineered to block CLEC14A-mediated signaling, aiming to disrupt pathological angiogenesis in cancers. Studies suggest that targeting CLEC14A with antibodies may inhibit tumor growth by normalizing abnormal vasculature or inducing antibody-dependent cellular cytotoxicity (ADCC).

Commercial CLEC14A antibodies are available for research, with validation in specific applications varying by clone and epitope specificity. Challenges include ensuring binding specificity due to potential glycosylation interference and cross-reactivity with other lectin family proteins. Ongoing research explores CLEC14A's role in vascular biology and its utility as a biomarker or therapeutic target in oncology.

       
关键字: CLEC14A抗体;CLEC14A;CLEC14A Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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