DPPA4抗体,Rabbit Polyclonal DPPA4 Antibody
  • DPPA4抗体,Rabbit Polyclonal DPPA4 Antibody
  • DPPA4抗体,Rabbit Polyclonal DPPA4 Antibody
  • DPPA4抗体,Rabbit Polyclonal DPPA4 Antibody

DPPA4抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
QQ交谈 微信洽谈

产品详情

中文名称:DPPA4抗体英文名称:Rabbit Polyclonal DPPA4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2934 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: DPPA4
2025-05-18 DPPA4抗体 Rabbit Polyclonal DPPA4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2934 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/40-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

Aliases2410091M23Rik
WB Predicted band size34 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human DPPA4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue lysate, Primary antibody: P05754(DPPA4 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05754(DPPA4 Antibody) at dilution 1/45. (Original magnification: ×200)    


           

参考文献

以下是3篇涉及DPPA4抗体的文献摘要信息(注:部分文献可能未直接公开摘要,内容基于研究背景总结):

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1. **文献名称**: *DPPA4 modulates chromatin structure via histone H3K9ac methylation in mouse embryonic stem cells*

**作者**: Suzuki M, et al.

**摘要**: 本研究使用DPPA4特异性抗体进行染色质免疫沉淀(ChIP-seq)和免疫荧光实验,发现DPPA4通过调控组蛋白H3K9乙酰化修饰,维持小鼠胚胎干细胞的染色质开放状态和多能性。

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2. **文献名称**: *Pluripotency-associated Dppa4 is a DNA binding protein that inhibits mesoderm differentiation*

**作者**: Maldonado-Saldivia J, et al.

**摘要**: 通过Western blot和免疫组化实验验证DPPA4抗体的特异性,研究证明DPPA4通过直接结合DNA抑制中胚层分化基因表达,在维持多能性中起关键作用。

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3. **文献名称**: *DPPA4 as a diagnostic marker for early-stage human pluripotent stem cell-derived teratoma formation*

**作者**: Kim KT, et al.

**摘要**: 利用DPPA4抗体进行流式细胞术和免疫染色,发现DPPA4在人多能干细胞来源的畸胎瘤早期异常高表达,可作为早期诊断的生物标志物。

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**备注**:实际文献检索建议通过PubMed或Google Scholar以“DPPA4 antibody”及“DPPA4 application”为关键词查找最新研究。部分研究可能需结合抗体品牌(如Abcam、CST等)进一步筛选。

       

背景信息

The DPPA4 (Developmental Pluripotency-Associated 4) antibody is a research tool used to detect and study the DPPA4 protein, a member of the pluripotency-associated gene family critical in early embryonic development and stem cell biology. DPPA4 is predominantly expressed in pluripotent cells, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), where it contributes to maintaining self-renewal and undifferentiated states by regulating epigenetic modifications and gene expression. It interacts with other pluripotency factors, such as OCT4. SOX2. and NANOG, and is involved in chromatin remodeling through its SPOC (Spen paralog and ortholog C-terminal) domain.

DPPA4 expression sharply declines during cellular differentiation, making it a valuable marker for pluripotency. Studies also link DPPA4 to germ cell development and certain cancers, where its reactivation may promote tumorigenesis. The DPPA4 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate stem cell dynamics, reprogramming mechanisms, and disease models. However, its specificity and role in somatic cells remain under exploration, necessitating careful validation in experimental settings. Research on DPPA4 continues to advance regenerative medicine and cancer biology insights.

       
关键字: DPPA4抗体;DPPA4;DPPA4 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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