ZNF7抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat and PC-3 cell lysates, Primary antibody: P05962(ZNF7 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

The zinc finger protein 7 (ZNF7) antibody is a tool used to study the ZNF7 protein, a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. These proteins are characterized by tandem C2H2-type zinc finger motifs, which enable sequence-specific DNA binding, and a KRAB domain that often mediates transcriptional repression through interactions with co-repressors. ZNF7 is implicated in gene regulation, chromatin remodeling, and epigenetic silencing, though its precise biological roles remain under investigation. Studies suggest potential involvement in developmental processes, cellular differentiation, and cancer, where dysregulation of zinc finger proteins may contribute to oncogenesis or tumor suppression.

ZNF7 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. They enable detection of ZNF7 in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Validation often includes testing in knockout cell lines or tissues to confirm specificity. Researchers use these antibodies to explore ZNF7's nuclear localization, DNA-binding behavior, and interactions with chromatin-modifying complexes. Recent interest has focused on its potential role in X-chromosome inactivation and retroelement silencing, aligning with broader studies on KRAB-ZNF proteins in genome stability and antiviral defense. Commercial availability from multiple suppliers facilitates its use in both basic and translational research contexts.